一种使用异烟肼测定乙酰化酶表型的简单方法。
A simple method for determining acetylator phenotype using isoniazid.
作者信息
Hutchings A, Routledge P A
出版信息
Br J Clin Pharmacol. 1986 Sep;22(3):343-5. doi: 10.1111/j.1365-2125.1986.tb02897.x.
Abstract
A comparison was made between the results of acetylator phenotyping by isoniazid (INH) half-life measurements based on samples taken for 6 h after a single oral dose (200 mg), and by determination of the ratio of acetylisoniazid (Ac.INH) to isoniazid in the 3 h samples. In the 32 subjects, examined, there was complete agreement about classification of the subject as a fast (t1/2 less than 130 min; Ac.INH/INH greater than 1.5) or slow acetylator (t1/2 greater than 130 min; Ac.INH/INH less than 1.5). The single sample test appears to be as reliable as the more time-consuming isoniazid half-life method.
摘要
通过单次口服剂量（200毫克）后6小时采集的样本，基于异烟肼（INH）半衰期测量进行乙酰化酶表型分析的结果，与通过测定3小时样本中乙酰异烟肼（Ac.INH）与异烟肼的比例进行分析的结果进行了比较。在所检查的32名受试者中，对于将受试者分类为快乙酰化者（半衰期小于130分钟；Ac.INH/INH大于1.5）或慢乙酰化者（半衰期大于130分钟；Ac.INH/INH小于1.5），两者完全一致。单样本测试似乎与更耗时的异烟肼半衰期方法一样可靠。
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