Sarker A B, Nashimuddin A N, Islam K M, Rabbani K S, Rahman M, Mushin A U, Hussain M
Department of Pathology, Okayama University Medical School, Japan.
Bangladesh Med Res Counc Bull. 1993 Dec;19(3):103-12.
The present experiment was designed to find out whether PEMF can act as a healing agent on induced fracture of rat tibia. Eighty rats were taken for this experiment. Under general anaesthesia mid-shaft of tibia and fibula of all rats were osteotomied, Intramedullary nailing was done for proper alignment of the fractured fragments. The animals were then divided into two groups: group-1 and Group-II. Each group contained forty animals. Out of these forty animals twenty were treated as experimental and twenty as control. From the third day of osteotomy, PEMF was applied to experimental rats around the osteotomy sites for a period of nine hours a day. PEMF was not applied to the control rats. The animals of group-1 and group-II were sacrificed after applied one week and three weeks of PEMF, respectively. Radiological and microscopical examination of the callus were performed. Gross and microscopic measurements of the callus were statistically analysed. The growth of callus was taken as a criterion of fracture healing. The results of the present experiment revealed significant enhancement of fracture healing in group-I. The results of the radiological evaluation of group-II experimental animals were also consistent with the morphological analysis. It was concluded that healing of fractured rat tibia was enhanced by the application of PEMF and this effect of PEMF was more pronounced at the end of third week.
本实验旨在探究脉冲电磁场（PEMF）是否能促进大鼠胫骨诱导性骨折的愈合。本实验选用了80只大鼠。在全身麻醉下，将所有大鼠的胫骨干中段和腓骨进行截骨，并采用髓内钉固定以使骨折碎片正确对位。然后将动物分为两组：第一组和第二组。每组包含40只动物。在这40只动物中，20只作为实验组，20只作为对照组。从截骨术后第三天开始，对实验组大鼠在截骨部位周围施加PEMF，每天持续9小时。对照组大鼠不施加PEMF。分别在施加PEMF一周和三周后，对第一组和第二组的动物进行处死。对骨痂进行放射学和显微镜检查。对骨痂的大体和微观测量结果进行统计学分析。将骨痂的生长作为骨折愈合的标准。本实验结果显示，第一组的骨折愈合有显著增强。第二组实验动物的放射学评估结果也与形态学分析一致。得出的结论是，施加PEMF可促进大鼠胫骨骨折的愈合，且这种PEMF的作用在第三周结束时更为明显。
