通过药物预处理预防术中心肌损伤。

Prevention of intraoperative myocardial injury by pretreatment with pharmacological agents.

作者信息

Hickey P A

机构信息

Clinic of Surgery, National Heart and Lung Institute, Bethesda, Md 20014.

出版信息

Ann Thorac Surg. 1975 Jul;20(1):101-5. doi: 10.1016/s0003-4975(10)63860-x.

DOI:10.1016/s0003-4975(10)63860-x

PMID:803168

Abstract

Pharmacological agents administered prior to the institution of myocardial anoxia or ischemia may protect the myocardium by preventing ATP depletion, structural damage to cell membranes and organelles, and postanoxic disturbances in coronary microcirculation. Propranolol, dipyridamole, nitroglycerin, and mannitol all have the potential to protect the myocardium in one or more of these ways and thus have promise for clinical use.

摘要

在心肌缺氧或缺血发生之前给予的药理制剂，可通过防止三磷酸腺苷（ATP）耗竭、细胞膜和细胞器的结构损伤以及缺氧后冠状动脉微循环紊乱来保护心肌。普萘洛尔、双嘧达莫、硝酸甘油和甘露醇都有可能以这些方式中的一种或多种来保护心肌，因此具有临床应用前景。