术中心肌保护的实验室评估。对合适动物模型的需求。

Laboratory evaluation of intraoperative myocardial protection. The need for appropriate animal models.

作者信息

Reitz B A

机构信息

Clinic of Surgery, National Heart and Lung Institute, Bethesda, Md. 20014.

出版信息

Ann Thorac Surg. 1975 Jul;20(1):7-10. doi: 10.1016/s0003-4975(10)63844-1.

DOI:10.1016/s0003-4975(10)63844-1

PMID:803174

Abstract

The investigative laboratory is the appropriate place to evaluate methods of intraoperative myocardial protection. It is becoming apparent that diseased myocardium is more susceptible to intraoperative injury than is normal heart muscle, and so animal models that simulate human cardiac disease states such as chronic left ventricular hypertrophy should be used to assess various techniques. Long-term studies on animals surviving operation are necessary in order to evaluate the chronic effects of various methods of protection.

摘要

研究实验室是评估术中心肌保护方法的合适场所。越来越明显的是，患病心肌比正常心肌更容易受到术中损伤，因此应使用模拟人类心脏疾病状态（如慢性左心室肥厚）的动物模型来评估各种技术。为了评估各种保护方法的长期影响，对术后存活的动物进行长期研究是必要的。