Gonzalez B, Heiba I M, Gerszencveig R, Sepulveda R L, Elston R C, Sorensen R U
Department of Pediatrics, Hospital Luis Calvo Mackenna, University of Chile Medical School, Santiago.
Tuber Lung Dis. 1994 Apr;75(2):144-8. doi: 10.1016/0962-8479(94)90044-2.
Some infants immunized with BCG in the newborn period fail to develop any measurable tuberculin reactivity despite a local reaction at the site of immunization.
We wished to determine the possibility of a genetic regulation of this phenomenon by comparing the tuberculin reactivity of BCG-immunized parents and siblings of infants who failed to respond to BCG, and of infants who developed tuberculin reactivity after immunization.
We studied 65 parents and siblings of 33 nonresponder infants, and 35 parents and siblings of 14 infants who had developed tuberculin reactivity. Tuberculin reactivity was analyzed by multiple regression analysis considering the BCG immunization status of each individual, and the 2 groups were compared by analysis of covariance.
96 of these family members had one or more BCG scars. The percentages of tuberculin reactors and non-reactors among BCG-immunized family members of both index infant groups were not significantly different.
These observations suggest that maturational differences among newborns, rather than genetic regulation, account for the lack of development of cellular immunity against tuberculin after BCG immunization in some infants.
一些在新生儿期接种卡介苗的婴儿尽管在接种部位出现局部反应，但仍未产生任何可测量的结核菌素反应性。
我们希望通过比较未对卡介苗产生反应的婴儿以及接种后产生结核菌素反应性的婴儿的接种卡介苗的父母和兄弟姐妹的结核菌素反应性，来确定这种现象的基因调控可能性。
我们研究了33名无反应婴儿的65名父母和兄弟姐妹，以及14名产生结核菌素反应性的婴儿的35名父母和兄弟姐妹。通过多元回归分析考虑每个个体的卡介苗接种状况来分析结核菌素反应性，并通过协方差分析比较这两组。
这些家庭成员中有96人有一个或多个卡介苗疤痕。两个指数婴儿组的接种卡介苗的家庭成员中结核菌素反应者和无反应者的百分比没有显著差异。
这些观察结果表明，新生儿之间的成熟差异而非基因调控是导致一些婴儿接种卡介苗后缺乏针对结核菌素的细胞免疫发展的原因。
