Sepulveda R L, Heiba I M, King A, Gonzalez B, Elston R C, Sorensen R U
Department of Medicine, University of Chile Medical School, Santiago.
Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):620-4. doi: 10.1164/ajrccm.149.3.8118628.
The purpose of the present study was to determine in BCG-immunized sibships < or = 14 yr of age whether the correlations of intensity of tuberculin reactivity support a genetic regulation of the response to BCG immunization. The study population consisted of 659 healthy children living in 265 households exposed to an adult with tuberculosis: 38 children did not have a BCG scar, 327 children had one BCG scar, and 294 had two BCG scars from vaccinations at birth and at 6 yr of age. There were 603 full siblings, 16 half-siblings, and 40 unrelated children. Tuberculin testing was performed by one trained nurse. Sibling correlations of the intensity of the tuberculin response were calculated after adjusting for various nongenetic covariates that could be important in predicting it. The sibling correlations were significant at the 1% significance level. There was no significant correlation of tuberculin reactivity among unrelated children in the same household. These results are consistent with genetic regulation of the development and persistence of tuberculin reactivity after BCG immunization.
本研究的目的是确定在年龄小于或等于14岁、接种过卡介苗的同胞手足中，结核菌素反应强度的相关性是否支持对卡介苗免疫反应的遗传调控。研究人群包括居住在265户有成人结核病患者家庭中的659名健康儿童：38名儿童没有卡介苗疤痕，327名儿童有一处卡介苗疤痕，294名儿童因出生时和6岁时接种疫苗有两处卡介苗疤痕。有603名全同胞手足、16名单同胞手足和40名无血缘关系的儿童。结核菌素检测由一名经过培训的护士进行。在对各种可能对预测结核菌素反应强度重要的非遗传协变量进行调整后，计算了结核菌素反应强度的同胞手足相关性。同胞手足相关性在1%的显著性水平上具有显著性。同一家庭中无血缘关系的儿童之间结核菌素反应性无显著相关性。这些结果与卡介苗免疫后结核菌素反应性的发育和持续存在的遗传调控一致。
