位置效应斑驳与异染色质新生物学

Position-effect variegation and the new biology of heterochromatin.

作者信息

Karpen G H

机构信息

Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037-1099.

出版信息

Curr Opin Genet Dev. 1994 Apr;4(2):281-91. doi: 10.1016/s0959-437x(05)80055-3.

DOI:10.1016/s0959-437x(05)80055-3

PMID:8032206

Abstract

The phenomenon of position-effect variegation has long been used as evidence for the importance of chromosome position to gene expression in eukaryotes. Investigations published within the past few years demonstrate that position-effect variegation is caused by multiple mechanisms, and that direct tests of hypotheses are possible with numerous model systems.

摘要

位置效应斑驳现象长期以来一直被用作证据，证明染色体位置对真核生物基因表达的重要性。过去几年发表的研究表明，位置效应斑驳是由多种机制引起的，并且利用众多模型系统可以对各种假说进行直接验证。