Hashimoto S, Nakamura K, Honma S, Honma K
Department of Physiology, Hokkaido University School of Medicine, Sapporo, Japan.
Psychiatry Clin Neurosci. 1998 Apr;52(2):264-5. doi: 10.1111/j.1440-1819.1998.tb01066.x.
A long-term observation of a sighted man who developed a non-24 h sleep-wake syndrome is reported. A partial entrainment was observed first, whereby the sleep-wake rhythm was entrained by the day-night alternation whereas the circadian rhythm in plasma melatonin was free-running. Two years later, the sleep-wake rhythm of this subject started to free-run together with the melatonin rhythm. Oral administration of melatonin for 2 weeks improved the entrainability of both rhythms but failed to entrain the rhythms completely. It is concluded that the free-running of the circadian pacemaker preceded a full manifestation of a non-24 h sleep-wake syndrome in this particular subject.
报告了一名视力正常男子出现非24小时睡眠-觉醒综合征的长期观察情况。首先观察到部分同步化现象，即睡眠-觉醒节律由昼夜交替同步，而血浆褪黑素的昼夜节律呈自由运转状态。两年后，该受试者的睡眠-觉醒节律开始与褪黑素节律一起自由运转。口服褪黑素2周改善了两种节律的同步性，但未能使节律完全同步。结论是，在该特定受试者中，昼夜起搏器的自由运转先于非24小时睡眠-觉醒综合征的完全表现。
