Baettig D, Tillement J P, Baumann P
Centre médico-psychologique, Service de psychiatrie pour adultes, Delémont, Switzerland.
Int J Clin Pharmacol Ther. 1994 Apr;32(4):165-7.
A 62-year-old male patient, suffering from a hypertensive cardiopathy, an arteriopathy of the lower extremities and a type II insulin independent diabetes had a prothrombin time ratio R of 2.15 (therapeutic range: 2.1-1.45) during a daily treatment of 4-6 mg acenocoumarin. On admission to the psychiatric hospital for depression, a mianserin treatment was commenced, leading to a sharp modification in the PT ratio R, in effect that the acenocoumarin treatment had to be increased to keep R within the therapeutic range. The possible mechanism of this interaction between mianserin and acenocoumarin is discussed, taking into account the possible role of the comedicated amiodarone.
一名62岁男性患者，患有高血压性心脏病、下肢动脉病和II型非胰岛素依赖型糖尿病，在每日服用4 - 6毫克醋硝香豆素进行治疗期间，其凝血酶原时间比值R为2.15（治疗范围：2.1 - 1.45）。在因抑郁症入住精神病院时，开始使用米安色林治疗，这导致凝血酶原时间比值R急剧变化，实际上不得不增加醋硝香豆素的治疗剂量以将R维持在治疗范围内。考虑到同时使用的胺碘酮可能发挥的作用，对米安色林与醋硝香豆素之间这种相互作用的可能机制进行了讨论。
