Kamalian N, Keesey R E, ZuRhein G M
Neurology. 1975 Jan;25(1):25-30. doi: 10.1212/wnl.25.1.25.
A 41-year old woman had profound weight loss and cachexia as a manifestation of rapidly fatal multiple sclerosis. Demyelinating lesions were present in the lateral hypothalamus. Data from animal experiments have indicated that lateral hypothalamic lesions cause a weight loss associated with a lowering of the regulation level or "set-point" for body weight. This case suggests, therefore, that a rapid decline in the level of maintained body weight in a patient without pituitary disease or general organic disorder, or distinct emotional disorder, may represent a clinical manifestation of tissue injury of the lateral hypothalamus.
一名41岁女性出现严重体重减轻和恶病质，这是快速进展性致命性多发性硬化症的表现。下丘脑外侧存在脱髓鞘病变。动物实验数据表明，下丘脑外侧病变会导致体重减轻，并伴有体重调节水平或“设定点”降低。因此，该病例提示，在没有垂体疾病、全身性器质性疾病或明显情绪障碍的患者中，维持体重水平的快速下降可能代表下丘脑外侧组织损伤的临床表现。
