肿瘤坏死因子-α（TNF-α）-308位点多态性与强直性脊柱炎的关系
Polymorphism of tumour necrosis factor-alpha (TNF-alpha) at position -308 in relation to ankylosing spondylitis.
作者信息
Verjans G M, Brinkman B M, Van Doornik C E, Kijlstra A, Verweij C L
机构信息
Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, Amsterdam.
出版信息
Clin Exp Immunol. 1994 Jul;97(1):45-7. doi: 10.1111/j.1365-2249.1994.tb06577.x.
Abstract
In addition to HLA-B27, other genetic factors are thought to be involved in the pathogenesis of ankylosing spondylitis (AS). Because of the localization, in the proximity of the HLA-B locus, and the biological activities of TNF-alpha, we investigated the association between AS and a single base polymorphism located at position -308 of the TNF-alpha gene. An allele-specific polymerase chain reaction was developed to monitor this polymorphism. The frequency of the TNF-alpha alleles was determined in 66 AS patients and 37 healthy controls. The TNF-alpha allele frequency was not significantly different between AS patients and controls.
摘要
除HLA - B27外，其他遗传因素也被认为与强直性脊柱炎（AS）的发病机制有关。由于肿瘤坏死因子-α（TNF-α）的定位靠近HLA - B基因座且具有生物学活性，我们研究了AS与位于TNF-α基因-308位的单碱基多态性之间的关联。我们开发了一种等位基因特异性聚合酶链反应来监测这种多态性。在66例AS患者和37例健康对照中测定了TNF-α等位基因的频率。AS患者和对照组之间的TNF-α等位基因频率无显著差异。
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