Zhu C S, Zhang C Y, Weng W Q
Affiliated Hospital, Qingdao Medical College.
Zhonghua Zhong Liu Za Zhi. 1994 Jan;16(1):39-42.
Serum superoxide dismutase (SOD) activity and blood Cu/Zn SOD content were examined in 102 cases of leukemia. The results showed that the total SOD activities, Cu/Zn SOD activities and contents declined significantly in blast phase of acute leukemia, yet increased to normal levels in remission. There was a positive correlation between SOD and blood hemoglobin concentration as well as leucocyte count. It declined again when leukemia recurred and in dying patients. There was a dissociation between Cu/Zn SOD activities and contents in patients with chronic granulocytic leukemia. In chronic lymphocytic leukemia, both activity and contents of SOD were normal. It was suggested that SOD plays a protective role during the occurrence and development of leukemia. SOD is a useful parameter in the differential diagnosis of leukemias and monitoring clinical course of leukemias.
检测了102例白血病患者的血清超氧化物歧化酶（SOD）活性及血液铜/锌超氧化物歧化酶含量。结果显示，急性白血病急变期总SOD活性、铜/锌超氧化物歧化酶活性及含量显著下降，但缓解期升高至正常水平。SOD与血液血红蛋白浓度及白细胞计数呈正相关。白血病复发及濒死患者时其又下降。慢性粒细胞白血病患者铜/锌超氧化物歧化酶活性与含量存在分离现象。慢性淋巴细胞白血病患者SOD活性及含量均正常。提示SOD在白血病发生发展过程中起保护作用。SOD是白血病鉴别诊断及监测白血病临床病程的有用参数。
