Gonzales R, Auclair C, Voisin E, Gautero H, Dhermy D, Boivin P
Cancer Res. 1984 Sep;44(9):4137-9.
Superoxide dismutase (SOD), catalase, and glutathione peroxidase activities have been determined in red blood cells isolated from patients with acute myelogenous leukemia, chronic lymphocytic leukemia, Hodgkin's disease, lymphosarcoma, and various visceral cancers. In all investigated cases, both catalase and glutathione peroxidase were found to be in normal ranges of activity. In the group of patients with visceral cancers, SOD activity was found to be normal as well. In contrast, SOD activity was found to be significantly increased in red blood cells from patients with acute myelogenous leukemia and lymphoproliferative syndromes. This increase in superoxide level was not related to either reticulocytosis or hypochromic anemia. No relationship was found between the SOD level and the stage, the extension of the disease, or the presence of an inflammatory syndrome. The highest SOD levels were observed in untreated patients or during the early time period of the treatment. SOD levels further decrease as a function of the increase in the duration of the treatment. These results suggest an abnormality in the regulation of the expression of the SOD gene in the pluripotent stem cells.
已对从急性髓性白血病、慢性淋巴细胞白血病、霍奇金病、淋巴肉瘤及各种内脏癌患者中分离出的红细胞中的超氧化物歧化酶（SOD）、过氧化氢酶和谷胱甘肽过氧化物酶活性进行了测定。在所有研究病例中，均发现过氧化氢酶和谷胱甘肽过氧化物酶活性处于正常范围。在内脏癌患者组中，SOD活性也被发现正常。相比之下，在急性髓性白血病和淋巴增殖综合征患者的红细胞中，SOD活性显著增加。超氧化物水平的这种增加与网织红细胞增多症或低色素性贫血均无关。未发现SOD水平与疾病分期、疾病扩展或炎症综合征的存在之间存在关联。在未经治疗的患者或治疗早期观察到最高的SOD水平。SOD水平随着治疗持续时间的增加而进一步降低。这些结果提示多能干细胞中SOD基因表达的调节存在异常。
