Goettsch W, Garssen J, Deijns A, de Gruijl F R, van Loveren H
National Institute for Public Health and Environmental Protection, Bilthoven.
Environ Health Perspect. 1994 Mar;102(3):298-301. doi: 10.1289/ehp.94102298.
To assess the possibility that increases in UV-B exposure on the earth's surface could lead to impaired resistance to several infectious diseases, we studied the effect of UV-B exposure on resistance against Trichinella spiralis. Wistar rats, orally infected with T. spiralis larvae, were exposed to suberythemal doses of UV-B radiation daily for 5 days at different time periods before or after infection. A significant increase in the number of Trichinella larvae was found in the carcasses of rats irradiated with UV-B between 6 and 10 days after infection. These data indicate that exposure to UV-B radiation suppresses the resistance to a parasitic infection. We suggested that UV-B radiation especially suppresses cellular immune responses against these worms because specific IgM, IgG, and IgE titers were not significantly altered by UV-B exposure. These data indicate that UV-B irradiation plays a role in the course of infection with T. spiralis, which suggests that increases of UV-B exposure might also lead to problems with other infectious diseases and might affect vaccination because of the interaction of UV-B irradiation with memory T-cells.
为评估地球表面紫外线B（UV-B）照射增加可能导致对几种传染病抵抗力受损的可能性，我们研究了UV-B照射对抵抗旋毛虫能力的影响。将经口感染旋毛虫幼虫的Wistar大鼠在感染前或感染后的不同时间段，每天接受亚红斑剂量的UV-B辐射，持续5天。在感染后6至10天接受UV-B照射的大鼠尸体中，发现旋毛虫幼虫数量显著增加。这些数据表明，UV-B辐射会抑制对寄生虫感染的抵抗力。我们认为UV-B辐射尤其会抑制针对这些蠕虫的细胞免疫反应，因为UV-B照射并未显著改变特异性IgM、IgG和IgE滴度。这些数据表明，UV-B照射在旋毛虫感染过程中起作用，这表明UV-B照射增加也可能导致其他传染病出现问题，并可能因UV-B照射与记忆T细胞的相互作用而影响疫苗接种。
