Rocchi E, Borella P, Borghi A, Paolillo F, Pradelli M, Farina F, Casalgrandi G
Chair of Terapia Medica, University of Modena, Italy.
Eur J Clin Invest. 1994 Mar;24(3):149-55. doi: 10.1111/j.1365-2362.1994.tb00980.x.
The Authors determined zinc (Zn) and magnesium (Mg) in the plasma, urine, erythrocytes (RBCs), mono- and polymorphonuclear cells (MNCs and PMNs) of patients with overt alcoholic and non-alcoholic liver cirrhosis. In order to obtain a clearer clinical picture, biochemical and nutritional parameters (retinol, tocopherol, six different carotenoids, creatinine-height index and tricipital skinfold), as well as markers of portal hypertension (spleno-portal size and platelet count) were also evaluated. The plasma levels of Zn and Mg were found to be reduced, as were the urine levels of Mg. Urine Zn, on the other hand, was higher than normal. Plasma Zn correlated inversely, and urine Zn directly, with the severity of the disease, rather than with alcohol consumption or treatment with diuretics. Protein metabolism impairment would appear to affect the plasma transport of Zn rather than its overall availability in the organism; the opposite was found in the case of Mg, the availability of which appeared to be reduced. Determination of the two elements in RBCs, MNCs and PMNs suggested that a true nutritional deficit cannot be demonstrated. MNCs, rather than RBCs or PMNs seem better to reflect tissue status of trace elements.
作者测定了显性酒精性和非酒精性肝硬化患者血浆、尿液、红细胞（RBC）、单核细胞和多形核细胞（MNC和PMN）中的锌（Zn）和镁（Mg）。为了更清楚地了解临床情况，还评估了生化和营养参数（视黄醇、生育酚、六种不同的类胡萝卜素、肌酐身高指数和三头肌皮褶厚度）以及门静脉高压的标志物（脾门静脉大小和血小板计数）。发现血浆中Zn和Mg的水平降低，尿液中Mg的水平也降低。另一方面，尿液中Zn高于正常水平。血浆Zn与疾病严重程度呈负相关，尿液Zn与疾病严重程度呈正相关，而不是与酒精摄入量或利尿剂治疗有关。蛋白质代谢受损似乎影响Zn的血浆转运，而不是其在机体中的总体可用性；而Mg的情况则相反，其可用性似乎降低。对RBC、MNC和PMN中这两种元素的测定表明，无法证明存在真正的营养缺乏。MNC似乎比RBC或PMN更能反映微量元素的组织状态。
