犬心脏缺血诱导的羟自由基的微透析研究。
Microdialysis study of ischemia-induced hydroxyl radicals in the canine heart.
作者信息
Timoshin A A, Tskitishvili O V, Serebryakova L I, Kuzmin A I, Medvedev O S, Ruuge E K
机构信息
Institute of Experimental Cardiology, Russian Academy of Medical Sciences, Moscow.
出版信息
Experientia. 1994 Jul 15;50(7):677-9. doi: 10.1007/BF01952872.
PMID:8033976
Abstract
A new experimental approach for spin-trapping of oxygen radicals in a selected region of the heart in situ is described. This approach is based on microdialysis, and it permits the detection of oxygen radicals in conditions of local ischemia and restoration of normal blood flow. Increased hydroxyl radical generation in an ischemic area of canine myocardium, as a result of 40 min local occlusion, has been studied.
摘要
本文描述了一种在心脏原位选定区域自旋捕获氧自由基的新实验方法。该方法基于微透析，可在局部缺血和恢复正常血流的条件下检测氧自由基。研究了犬心肌缺血区域因局部闭塞40分钟而导致的羟自由基生成增加的情况。
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