Maurer T A, Zackheim H S, Tuffanelli L, Berger T G
Department of Dermatology, University of San Francisco, CA.
J Am Acad Dermatol. 1994 Aug;31(2 Pt 2):372-5. doi: 10.1016/s0190-9622(94)70175-x.
The use of methotrexate (MTX) has been contraindicated for treatment of severe psoriasis in HIV infection on the basis of six previously reported cases in which MTX appeared to potentiate opportunistic infections and accelerate HIV disease. We describe three HIV-infected patients who were given MTX for severe psoriatic arthritis. In two patients opportunistic infections did not develop. On the basis of survival data, it is not clear that use of MTX adversely affected the natural course of their HIV disease.
基于先前报道的6例病例，甲氨蝶呤（MTX）被禁止用于治疗HIV感染患者的重度银屑病，在这些病例中MTX似乎会增强机会性感染并加速HIV疾病进展。我们描述了3例因重度银屑病关节炎接受MTX治疗的HIV感染患者。其中2例患者未发生机会性感染。根据生存数据，尚不清楚MTX的使用是否对其HIV疾病的自然病程产生了不利影响。
