Imagawa H, Adachi S, Kaneko M, Ohtani M, Takano H, Katoh M, Ueda T, Bai H Z, Yoshioka Y, Ohnishi K
Department of Cardiovascular Surgery, Osaka Prefectural Hospital, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1994 Apr;42(4):537-44.
Surgical treatment has been employed in 52 patients (pts) with descending thoracic aortic aneurysm (DS-TAA). Based on the adjuncts during aneurysmal repair, the series is divided into 2 groups; simple aortic cross-clamping was utilized to manage the lesion in group SC (n = 42), while left heart bypass using a centrifugal pump was employed during the period of aortic occlusion in LHB group (n = 10). Of these 52 pts, 4 died in hospital (group SC:2, group LHB:2). The most common complication was the respiratory failure following the renal failure. No paraplegia occurred in both groups. Biochemistric measurements of alanine aminotransferase, creatinine (CRN) and amylase (AMY) showed no difference between group SC and group LHB. In pts of SC group with normal renal function, post-operative maximum (post Max) CRN during the first month had a logarithmic correlation with total aortic cross-clamp time (TAXT). The post Max CRN of LHB group with normal renal function remained less than 3.0 mg/dl even in the case with TAXT over 60 minutes. There is also a linear correlation of post Max AMY in pts of SC group. Late survival at 4 years, including hospital death, were 83% in SC group and 63% in LHB group. We conclude that DS-TAA cases with TAXT of less than 30 min with good distal organ function can be managed with simple aortic cross-clamping; otherwise usage of LHB was recommended to support distal circulation.
52例降主动脉瘤(DS-TAA)患者接受了手术治疗。根据动脉瘤修复过程中的辅助措施,该系列患者分为两组;SC组(n = 42)采用单纯主动脉交叉钳夹术处理病变,而LHB组(n = 10)在主动脉阻断期间使用离心泵进行左心转流。在这52例患者中,4例死于医院(SC组:2例,LHB组:2例)。最常见的并发症是肾衰竭后出现呼吸衰竭。两组均未发生截瘫。丙氨酸转氨酶、肌酐(CRN)和淀粉酶(AMY)的生化指标在SC组和LHB组之间无差异。在肾功能正常的SC组患者中,术后第一个月的最大肌酐值(术后最大值)与总主动脉交叉钳夹时间(TAXT)呈对数相关。即使TAXT超过60分钟,肾功能正常的LHB组患者术后最大值CRN仍低于3.0mg/dl。SC组患者术后最大值AMY也呈线性相关。包括医院死亡在内,SC组4年的晚期生存率为83%,LHB组为63%。我们得出结论,对于TAXT小于30分钟且远端器官功能良好的DS-TAA病例,可采用单纯主动脉交叉钳夹术进行处理;否则,建议使用LHB来支持远端循环。