Okazaki T, Yamataka A, Fujiwara T, Nishiye H, Fujimoto T, Miyano T
Department of Pediatric Surgery, Juntendo University School of Medicine, Tokyo, Japan.
J Pediatr Surg. 1994 May;29(5):655-8. doi: 10.1016/0022-3468(94)90734-x.
Smooth muscle biopsy specimens obtained from nine infants with infantile hypertrophic pyloric stenosis (IHPS) and from three controls were studied immunohistochemically with respect to the distribution of nerve terminals and neurofilaments. To label nerve terminals and neurofilaments, monoclonal antibodies (MAb) 171B5 and 2F11 were used, respectively. In all specimens of the control group, nerve terminals were numerous in both the myenteric plexus and the muscle layer. There were abundant neurofilaments in the myenteric plexus and a moderate number in the muscle layer. In all specimens of the IHPS group, the density of nerve terminals and neurofilaments was reduced in the muscle layer. In the myenteric plexus, there was no such reduction. The results indicate poor neuronal innervation of the muscle layer in the pylorus of infants with IHPS. This poor innervation may be related to the pathogenesis of pyloric stenosis and hypertrophy.
对从9例患有婴儿肥厚性幽门狭窄（IHPS）的婴儿以及3例对照者身上获取的平滑肌活检标本进行了免疫组织化学研究，以观察神经末梢和神经丝的分布情况。分别使用单克隆抗体（MAb）171B5和2F11来标记神经末梢和神经丝。在对照组的所有标本中，肌间神经丛和肌肉层中的神经末梢都很多。肌间神经丛中有丰富的神经丝，肌肉层中有中等数量的神经丝。在IHPS组的所有标本中，肌肉层中神经末梢和神经丝的密度降低。在肌间神经丛中，没有这种降低。结果表明，患有IHPS的婴儿幽门肌肉层的神经支配不良。这种神经支配不良可能与幽门狭窄和肥大的发病机制有关。
