Brun J G, Jonsson R, Haga H J
Centre of Rheumatology, Haukeland University Hospital, Bergen, Norway.
J Rheumatol. 1994 Apr;21(4):733-8.
To investigate if the plasma level of the granulocyte protein calprotectin is a useful indicator of severity of arthritis in patients with inflammatory rheumatic diseases, and to analyze which factors contribute to the raised plasma calprotectin levels.
Plasma calprotectin levels were measured by ELISA: In a cross sectional study of 154 patients with various inflammatory rheumatic diseases, calprotectin levels were correlated with laboratory and clinical variables.
The plasma levels of calprotectin and C-reactive protein (CRP) correlated significantly with the clinical evaluation of swollen joints (r = 0.51, p < or = 0.01 and r = 0.29, p < or = 0.01, respectively). Calprotectin levels, but not CRP levels or erythrocyte sedimentation rate, were significantly lower in patients with no swollen joints than in patients with one or more swollen joints (2613.6 micrograms/l vs 6287.0 micrograms/l, p < 0.001). A significant correlation between calprotectin and number of neutrophils was demonstrated (r = 0.43, p < or = 0.01), indicating that circulating neutrophils contribute to plasma calprotectin levels.
The plasma calprotectin level may be a useful indicator of arthritis in inflammatory rheumatic diseases.
研究粒细胞蛋白钙卫蛋白的血浆水平是否为炎症性风湿性疾病患者关节炎严重程度的有用指标，并分析哪些因素导致血浆钙卫蛋白水平升高。
采用酶联免疫吸附测定法（ELISA）检测血浆钙卫蛋白水平：在一项对154例各种炎症性风湿性疾病患者的横断面研究中，将钙卫蛋白水平与实验室及临床变量进行关联分析。
钙卫蛋白和C反应蛋白（CRP）的血浆水平与关节肿胀的临床评估显著相关（分别为r = 0.51，p≤0.01和r = 0.29，p≤0.01）。无关节肿胀患者的钙卫蛋白水平显著低于有一个或多个关节肿胀的患者（2613.6微克/升对6287.0微克/升，p < 0.001），而CRP水平和红细胞沉降率则无此差异。钙卫蛋白与中性粒细胞数量之间存在显著相关性（r = 0.43，p≤0.01），表明循环中的中性粒细胞对血浆钙卫蛋白水平有影响。
血浆钙卫蛋白水平可能是炎症性风湿性疾病中关节炎的有用指标。
