Wang Qin, Chen Weiqian, Lin Jin
Division of Rheumatology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
J Transl Int Med. 2019 Dec 31;7(4):126-131. doi: 10.2478/jtim-2019-0026. eCollection 2019 Dec.
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by inflammatory cell infiltration, high levels of cytokines, and erosion of cartilage and bone in joints. Calprotectin (CLP), as a recently described member of S100 family proteins, is a heterodimeric complex of S100A8 and S100A9. Currently, plenty of studies have indicated significantly increased serum and synovial fluid levels of CLP in patients with RA. It was reported that CLP was related to cell differentiation, migration, apoptosis, and production of pro-inflammatory factors in RA. In addition, there are the positive relationships between serum, synovial CLP and traditional acute phase reactants, disease activity, ultrasound and radiographic progression of joints, and treatment response of RA. In this review, we mainly discuss the role of CLP in the pathogenesis of RA as well as its potential to estimate clinical disease progression of RA patients.
类风湿性关节炎（RA）是一种炎症性自身免疫性疾病，其特征为炎症细胞浸润、细胞因子水平升高以及关节软骨和骨的侵蚀。钙卫蛋白（CLP）作为S100家族蛋白中最近被描述的成员，是S100A8和S100A9的异二聚体复合物。目前，大量研究表明RA患者血清和滑液中CLP水平显著升高。据报道，CLP与RA中的细胞分化、迁移、凋亡以及促炎因子的产生有关。此外，血清、滑膜CLP与传统急性期反应物、疾病活动度、关节超声和影像学进展以及RA的治疗反应之间存在正相关关系。在本综述中，我们主要讨论CLP在RA发病机制中的作用及其评估RA患者临床疾病进展的潜力。
