• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Anti-glucocorticoid effects of dehydroepiandrosterone (DHEA).

作者信息

Kalimi M, Shafagoj Y, Loria R, Padgett D, Regelson W

机构信息

Department of Physiology, Medical College of Virginia, Richmond 23298-0551.

出版信息

Mol Cell Biochem. 1994 Feb 23;131(2):99-104. doi: 10.1007/BF00925945.

DOI:10.1007/BF00925945
PMID:8035785
Abstract
摘要

相似文献

1
Anti-glucocorticoid effects of dehydroepiandrosterone (DHEA).脱氢表雄酮（DHEA）的抗糖皮质激素作用。
Mol Cell Biochem. 1994 Feb 23;131(2):99-104. doi: 10.1007/BF00925945.
2
Antiglucocorticoid action of dehydroepiandrosterone in young obese Zucker rats.脱氢表雄酮对年轻肥胖 Zucker 大鼠的抗糖皮质激素作用
Int J Obes Relat Metab Disord. 1992 Aug;16(8):579-83.
3
The native anti-glucocorticoid paradigm.天然抗糖皮质激素模式
J Steroid Biochem Mol Biol. 2006 Jul;100(1-3):95-105. doi: 10.1016/j.jsbmb.2006.03.001. Epub 2006 May 18.
4
Dehydroepiandrosterone and metyrapone partially restore the adaptive humoral and cellular immune response in endotoxin immunosuppressed mice.脱氢表雄酮和甲吡酮可部分恢复内毒素免疫抑制小鼠的适应性体液免疫和细胞免疫反应。
Innate Immun. 2014 Aug;20(6):585-97. doi: 10.1177/1753425913502243. Epub 2013 Sep 18.
5
DHEA, a selective glucocorticoid receptor antagonist: its role in immune system regulation and metabolism.脱氢表雄酮，一种选择性糖皮质激素受体拮抗剂：其在免疫系统调节和新陈代谢中的作用。
J Endocrinol Invest. 2002;25(10 Suppl):81-2.
6
Dehydroepiandrosterone functions as more than an antiglucocorticoid in preserving immunocompetence after thermal injury.脱氢表雄酮在热损伤后维持免疫能力方面的作用不止是作为一种抗糖皮质激素。
Endocrinology. 1995 Feb;136(2):393-401. doi: 10.1210/endo.136.2.7835270.
7
DHEA metabolism in arthritis: a role for the p450 enzyme Cyp7b at the immune-endocrine crossroad.关节炎中的脱氢表雄酮代谢：细胞色素P450酶Cyp7b在免疫-内分泌交叉点的作用
Ann N Y Acad Sci. 2006 Jun;1069:401-13. doi: 10.1196/annals.1351.038.
8
7α-hydroxylation of dehydroepiandrosterone does not interfere with the activation of glucocorticoids by 11β-hydroxysteroid dehydrogenase in E(t)C cerebellar neurons.7α-羟化脱氢表雄酮不会干扰 11β-羟类固醇脱氢酶在 E(t)C 小脑神经元中对糖皮质激素的激活。
J Steroid Biochem Mol Biol. 2013 Nov;138:290-7. doi: 10.1016/j.jsbmb.2013.07.001. Epub 2013 Jul 12.
9
Differential effects of adrenalectomy and starvation-refeeding on hepatic lipogenic responses to dehydroepiandrosterone and glucocorticoid in BHE and Sprague-Dawley rats.
J Nutr. 1988 Aug;118(8):1011-7. doi: 10.1093/jn/118.8.1011.
10
7-Hydroxydehydroepiandrosterone--a natural antiglucocorticoid and a candidate for steroid replacement therapy?
Physiol Res. 2000;49 Suppl 1:S107-12.

引用本文的文献

1
The Sex Hormone Precursors Dehydroepiandrosterone (DHEA) and Its Sulfate Ester Form (DHEAS): Molecular Mechanisms and Actions on Human Body.性激素前体脱氢表雄酮（DHEA）及其硫酸酯形式（DHEAS）：分子机制及其对人体的作用
Int J Mol Sci. 2025 Sep 3;26(17):8568. doi: 10.3390/ijms26178568.
2
Cortisol, DHEAS, and the cortisol/DHEAS ratio as predictors of epigenetic age acceleration.皮质醇、硫酸脱氢表雄酮以及皮质醇/硫酸脱氢表雄酮比值作为表观遗传年龄加速的预测指标。
Biogerontology. 2025 Aug 16;26(5):164. doi: 10.1007/s10522-025-10307-x.
3
Effect of a Broiler-Specific Light Spectrum on Growth Performance and Adrenocortical Activity in Chickens: A Pilot Study on a Commercial Farm.

本文引用的文献

1
AN ADRENAL-SECRETED "ANDROGEN": DEHYDROISOANDROSTERONE SULFATE. ITS METABOLISM AND A TENTATIVE GENERALIZATION ON THE METABOLISM OF OTHER STEROID CONJUGATES IN MAN.一种肾上腺分泌的“雄激素”：硫酸脱氢表雄酮。其代谢以及对人体其他甾体共轭物代谢的初步概括。
Recent Prog Horm Res. 1965;21:411-500.
2
Identification and isolation of dehydroisoandrosterone from peripheral human plasma.从人外周血血浆中鉴定和分离脱氢表雄酮
J Biol Chem. 1954 Aug;209(2):767-72.
3
Psychoneuroendocrine influences on immunocompetence and neoplasia.心理神经内分泌对免疫能力和肿瘤形成的影响。
特定肉鸡光谱对鸡生长性能和肾上腺皮质活动的影响：在商业农场进行的一项初步研究
Vet Sci. 2024 Dec 2;11(12):618. doi: 10.3390/vetsci11120618.
4
A Systematic Review of Metabolic Syndrome: Key Correlated Pathologies and Non-Invasive Diagnostic Approaches.代谢综合征的系统评价：关键相关病理及非侵入性诊断方法
J Clin Med. 2024 Oct 2;13(19):5880. doi: 10.3390/jcm13195880.
5
Dehydroepiandrosterone and Its Metabolite 5-Androstenediol: New Therapeutic Targets and Possibilities for Clinical Application.脱氢表雄酮及其代谢产物5-雄烯二醇：新的治疗靶点及临床应用前景
Pharmaceuticals (Basel). 2024 Sep 9;17(9):1186. doi: 10.3390/ph17091186.
6
The role of neuroactive steroids in tic disorders.神经活性甾体在抽动障碍中的作用。
Neurosci Biobehav Rev. 2024 May;160:105637. doi: 10.1016/j.neubiorev.2024.105637. Epub 2024 Mar 20.
7
The Metabolic Syndrome, a Human Disease.代谢综合征，一种人类疾病。
Int J Mol Sci. 2024 Feb 13;25(4):2251. doi: 10.3390/ijms25042251.
8
Effects of Opioid Withdrawal on Psychobiology in People Living with HIV.阿片类物质戒断对 HIV 感染者心理生物学的影响。
Viruses. 2024 Jan 6;16(1):92. doi: 10.3390/v16010092.
9
Dehydroepiandrosterone mediates associations between trauma-related symptoms and anterior pituitary volume in children and adolescents.脱氢表雄酮介导儿童和青少年创伤相关症状与垂体前叶体积之间的关联。
Hum Brain Mapp. 2023 Dec 15;44(18):6388-6398. doi: 10.1002/hbm.26516. Epub 2023 Oct 18.
10
Zoo Animal Welfare Assessment: Where Do We Stand?动物园动物福利评估：我们目前的状况如何？
Animals (Basel). 2023 Jun 12;13(12):1966. doi: 10.3390/ani13121966.
Science. 1981 Jun 5;212(4499):1100-9. doi: 10.1126/science.7233204.
4
Steroid hormones and aging: free testosterone, testosterone and androstenedione in normal females aged 20-87 years.
Hum Biol. 1980 May;52(2):181-91.
5
Developmental patterns of serum luteinizing hormone, gonadal and adrenal steroids in the sooty mangabey (Cercocebus atys).黑冠猕猴（Cercocebus atys）血清促黄体生成素、性腺和肾上腺类固醇的发育模式
Biol Reprod. 1983 Mar;28(2):279-84. doi: 10.1095/biolreprod28.2.279.
6
Steroid sulfotransferases and steroid sulfate sulfatases: characteristics and biological roles.
Can J Biochem Cell Biol. 1985 Nov;63(11):1127-44. doi: 10.1139/o85-141.
7
Adrenal androgen response to metyrapone, adrenocorticotropin, and corticotropin-releasing hormone stimulation in children with hypopituitarism.垂体功能减退症患儿对甲吡酮、促肾上腺皮质激素和促肾上腺皮质激素释放激素刺激的肾上腺雄激素反应。
J Clin Endocrinol Metab. 1987 Aug;65(2):282-9. doi: 10.1210/jcem-65-2-282.
8
Protection against acute lethal viral infections with the native steroid dehydroepiandrosterone (DHEA).
J Med Virol. 1988 Nov;26(3):301-14. doi: 10.1002/jmv.1890260310.
9
Physicochemical characterization of [3H] DHEA binding in rat liver.大鼠肝脏中[3H]脱氢表雄酮结合的物理化学特性
Biochem Biophys Res Commun. 1988 Oct 14;156(1):22-9. doi: 10.1016/s0006-291x(88)80800-3.
10
Differential effects of adrenalectomy and starvation-refeeding on hepatic lipogenic responses to dehydroepiandrosterone and glucocorticoid in BHE and Sprague-Dawley rats.
J Nutr. 1988 Aug;118(8):1011-7. doi: 10.1093/jn/118.8.1011.