脱氢表雄酮（DHEA）的抗糖皮质激素作用。 - Suppr

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Anti-glucocorticoid effects of dehydroepiandrosterone (DHEA).

作者信息

Kalimi M, Shafagoj Y, Loria R, Padgett D, Regelson W

机构信息

Department of Physiology, Medical College of Virginia, Richmond 23298-0551.

出版信息

Mol Cell Biochem. 1994 Feb 23;131(2):99-104. doi: 10.1007/BF00925945.

DOI:10.1007/BF00925945

PMID:8035785

Abstract

摘要

相似文献

Anti-glucocorticoid effects of dehydroepiandrosterone (DHEA).

Mol Cell Biochem. 1994 Feb 23;131(2):99-104. doi: 10.1007/BF00925945.

Antiglucocorticoid action of dehydroepiandrosterone in young obese Zucker rats.

Int J Obes Relat Metab Disord. 1992 Aug;16(8):579-83.

The native anti-glucocorticoid paradigm.

J Steroid Biochem Mol Biol. 2006 Jul;100(1-3):95-105. doi: 10.1016/j.jsbmb.2006.03.001. Epub 2006 May 18.

Dehydroepiandrosterone and metyrapone partially restore the adaptive humoral and cellular immune response in endotoxin immunosuppressed mice.

Innate Immun. 2014 Aug;20(6):585-97. doi: 10.1177/1753425913502243. Epub 2013 Sep 18.

DHEA, a selective glucocorticoid receptor antagonist: its role in immune system regulation and metabolism.

J Endocrinol Invest. 2002;25(10 Suppl):81-2.

Dehydroepiandrosterone functions as more than an antiglucocorticoid in preserving immunocompetence after thermal injury.

Endocrinology. 1995 Feb;136(2):393-401. doi: 10.1210/endo.136.2.7835270.

DHEA metabolism in arthritis: a role for the p450 enzyme Cyp7b at the immune-endocrine crossroad.

Ann N Y Acad Sci. 2006 Jun;1069:401-13. doi: 10.1196/annals.1351.038.

7α-hydroxylation of dehydroepiandrosterone does not interfere with the activation of glucocorticoids by 11β-hydroxysteroid dehydrogenase in E(t)C cerebellar neurons.

J Steroid Biochem Mol Biol. 2013 Nov;138:290-7. doi: 10.1016/j.jsbmb.2013.07.001. Epub 2013 Jul 12.

Differential effects of adrenalectomy and starvation-refeeding on hepatic lipogenic responses to dehydroepiandrosterone and glucocorticoid in BHE and Sprague-Dawley rats.

J Nutr. 1988 Aug;118(8):1011-7. doi: 10.1093/jn/118.8.1011.

7-Hydroxydehydroepiandrosterone--a natural antiglucocorticoid and a candidate for steroid replacement therapy?

Physiol Res. 2000;49 Suppl 1:S107-12.

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本文引用的文献

AN ADRENAL-SECRETED "ANDROGEN": DEHYDROISOANDROSTERONE SULFATE. ITS METABOLISM AND A TENTATIVE GENERALIZATION ON THE METABOLISM OF OTHER STEROID CONJUGATES IN MAN.

Recent Prog Horm Res. 1965;21:411-500.

Identification and isolation of dehydroisoandrosterone from peripheral human plasma.

J Biol Chem. 1954 Aug;209(2):767-72.

Psychoneuroendocrine influences on immunocompetence and neoplasia.

Science. 1981 Jun 5;212(4499):1100-9. doi: 10.1126/science.7233204.

Steroid hormones and aging: free testosterone, testosterone and androstenedione in normal females aged 20-87 years.

Hum Biol. 1980 May;52(2):181-91.

Developmental patterns of serum luteinizing hormone, gonadal and adrenal steroids in the sooty mangabey (Cercocebus atys).

Biol Reprod. 1983 Mar;28(2):279-84. doi: 10.1095/biolreprod28.2.279.

Steroid sulfotransferases and steroid sulfate sulfatases: characteristics and biological roles.

Can J Biochem Cell Biol. 1985 Nov;63(11):1127-44. doi: 10.1139/o85-141.

Adrenal androgen response to metyrapone, adrenocorticotropin, and corticotropin-releasing hormone stimulation in children with hypopituitarism.

J Clin Endocrinol Metab. 1987 Aug;65(2):282-9. doi: 10.1210/jcem-65-2-282.

Protection against acute lethal viral infections with the native steroid dehydroepiandrosterone (DHEA).

J Med Virol. 1988 Nov;26(3):301-14. doi: 10.1002/jmv.1890260310.

Physicochemical characterization of [3H] DHEA binding in rat liver.

Biochem Biophys Res Commun. 1988 Oct 14;156(1):22-9. doi: 10.1016/s0006-291x(88)80800-3.

Differential effects of adrenalectomy and starvation-refeeding on hepatic lipogenic responses to dehydroepiandrosterone and glucocorticoid in BHE and Sprague-Dawley rats.

J Nutr. 1988 Aug;118(8):1011-7. doi: 10.1093/jn/118.8.1011.

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Anti-glucocorticoid effects of dehydroepiandrosterone (DHEA).

作者信息

Kalimi M, Shafagoj Y, Loria R, Padgett D, Regelson W

机构信息

Department of Physiology, Medical College of Virginia, Richmond 23298-0551.

出版信息

Mol Cell Biochem. 1994 Feb 23;131(2):99-104. doi: 10.1007/BF00925945.

DOI:10.1007/BF00925945

PMID:8035785

Abstract

摘要

相似文献

Anti-glucocorticoid effects of dehydroepiandrosterone (DHEA).

Mol Cell Biochem. 1994 Feb 23;131(2):99-104. doi: 10.1007/BF00925945.

Antiglucocorticoid action of dehydroepiandrosterone in young obese Zucker rats.

Int J Obes Relat Metab Disord. 1992 Aug;16(8):579-83.

The native anti-glucocorticoid paradigm.

J Steroid Biochem Mol Biol. 2006 Jul;100(1-3):95-105. doi: 10.1016/j.jsbmb.2006.03.001. Epub 2006 May 18.

Dehydroepiandrosterone and metyrapone partially restore the adaptive humoral and cellular immune response in endotoxin immunosuppressed mice.

Innate Immun. 2014 Aug;20(6):585-97. doi: 10.1177/1753425913502243. Epub 2013 Sep 18.

DHEA, a selective glucocorticoid receptor antagonist: its role in immune system regulation and metabolism.

J Endocrinol Invest. 2002;25(10 Suppl):81-2.

Dehydroepiandrosterone functions as more than an antiglucocorticoid in preserving immunocompetence after thermal injury.

Endocrinology. 1995 Feb;136(2):393-401. doi: 10.1210/endo.136.2.7835270.

DHEA metabolism in arthritis: a role for the p450 enzyme Cyp7b at the immune-endocrine crossroad.

Ann N Y Acad Sci. 2006 Jun;1069:401-13. doi: 10.1196/annals.1351.038.

7α-hydroxylation of dehydroepiandrosterone does not interfere with the activation of glucocorticoids by 11β-hydroxysteroid dehydrogenase in E(t)C cerebellar neurons.

J Steroid Biochem Mol Biol. 2013 Nov;138:290-7. doi: 10.1016/j.jsbmb.2013.07.001. Epub 2013 Jul 12.

Differential effects of adrenalectomy and starvation-refeeding on hepatic lipogenic responses to dehydroepiandrosterone and glucocorticoid in BHE and Sprague-Dawley rats.

J Nutr. 1988 Aug;118(8):1011-7. doi: 10.1093/jn/118.8.1011.

7-Hydroxydehydroepiandrosterone--a natural antiglucocorticoid and a candidate for steroid replacement therapy?

Physiol Res. 2000;49 Suppl 1:S107-12.

引用本文的文献

The Sex Hormone Precursors Dehydroepiandrosterone (DHEA) and Its Sulfate Ester Form (DHEAS): Molecular Mechanisms and Actions on Human Body.

Int J Mol Sci. 2025 Sep 3;26(17):8568. doi: 10.3390/ijms26178568.

Cortisol, DHEAS, and the cortisol/DHEAS ratio as predictors of epigenetic age acceleration.

Biogerontology. 2025 Aug 16;26(5):164. doi: 10.1007/s10522-025-10307-x.

Effect of a Broiler-Specific Light Spectrum on Growth Performance and Adrenocortical Activity in Chickens: A Pilot Study on a Commercial Farm.

Vet Sci. 2024 Dec 2;11(12):618. doi: 10.3390/vetsci11120618.

A Systematic Review of Metabolic Syndrome: Key Correlated Pathologies and Non-Invasive Diagnostic Approaches.

J Clin Med. 2024 Oct 2;13(19):5880. doi: 10.3390/jcm13195880.

Dehydroepiandrosterone and Its Metabolite 5-Androstenediol: New Therapeutic Targets and Possibilities for Clinical Application.

Pharmaceuticals (Basel). 2024 Sep 9;17(9):1186. doi: 10.3390/ph17091186.

The role of neuroactive steroids in tic disorders.

Neurosci Biobehav Rev. 2024 May;160:105637. doi: 10.1016/j.neubiorev.2024.105637. Epub 2024 Mar 20.

The Metabolic Syndrome, a Human Disease.

Int J Mol Sci. 2024 Feb 13;25(4):2251. doi: 10.3390/ijms25042251.

Effects of Opioid Withdrawal on Psychobiology in People Living with HIV.

Viruses. 2024 Jan 6;16(1):92. doi: 10.3390/v16010092.

Dehydroepiandrosterone mediates associations between trauma-related symptoms and anterior pituitary volume in children and adolescents.

Hum Brain Mapp. 2023 Dec 15;44(18):6388-6398. doi: 10.1002/hbm.26516. Epub 2023 Oct 18.

Zoo Animal Welfare Assessment: Where Do We Stand?

Animals (Basel). 2023 Jun 12;13(12):1966. doi: 10.3390/ani13121966.

本文引用的文献

AN ADRENAL-SECRETED "ANDROGEN": DEHYDROISOANDROSTERONE SULFATE. ITS METABOLISM AND A TENTATIVE GENERALIZATION ON THE METABOLISM OF OTHER STEROID CONJUGATES IN MAN.

Recent Prog Horm Res. 1965;21:411-500.

Identification and isolation of dehydroisoandrosterone from peripheral human plasma.

J Biol Chem. 1954 Aug;209(2):767-72.

Psychoneuroendocrine influences on immunocompetence and neoplasia.

Science. 1981 Jun 5;212(4499):1100-9. doi: 10.1126/science.7233204.

Steroid hormones and aging: free testosterone, testosterone and androstenedione in normal females aged 20-87 years.

Hum Biol. 1980 May;52(2):181-91.

Developmental patterns of serum luteinizing hormone, gonadal and adrenal steroids in the sooty mangabey (Cercocebus atys).

Biol Reprod. 1983 Mar;28(2):279-84. doi: 10.1095/biolreprod28.2.279.

Steroid sulfotransferases and steroid sulfate sulfatases: characteristics and biological roles.

Can J Biochem Cell Biol. 1985 Nov;63(11):1127-44. doi: 10.1139/o85-141.

Adrenal androgen response to metyrapone, adrenocorticotropin, and corticotropin-releasing hormone stimulation in children with hypopituitarism.

J Clin Endocrinol Metab. 1987 Aug;65(2):282-9. doi: 10.1210/jcem-65-2-282.

Protection against acute lethal viral infections with the native steroid dehydroepiandrosterone (DHEA).

J Med Virol. 1988 Nov;26(3):301-14. doi: 10.1002/jmv.1890260310.

Physicochemical characterization of [3H] DHEA binding in rat liver.

Biochem Biophys Res Commun. 1988 Oct 14;156(1):22-9. doi: 10.1016/s0006-291x(88)80800-3.

Differential effects of adrenalectomy and starvation-refeeding on hepatic lipogenic responses to dehydroepiandrosterone and glucocorticoid in BHE and Sprague-Dawley rats.

J Nutr. 1988 Aug;118(8):1011-7. doi: 10.1093/jn/118.8.1011.