Danielisová V, Chavko M, Schubert P H
Department of Neurochemistry, Slovak Academy of Sciences, Kosice.
Neuropharmacology. 1994 Feb;33(2):199-204. doi: 10.1016/0028-3908(94)90008-6.
The effect of propentofylline on metabolic and functional recovery in the spinal cord after ischemia and reperfusion was investigated. Ischemia was induced by abdominal aorta ligation below the left renal artery for 20 or 30 min. Propentofylline (1, 5, 10 and 20 mg/kg) was administered intravenously, immediately after reperfusion and the animals recovered for 4 days. Propentofylline at a dose of 1 mg/kg and 5 mg/kg had only a slight effect on energy metabolism recovery in the spinal cord and neurological recovery of hindlimbs. However, almost complete recovery of adenine nucleotides, lactate and glucose occurred after 20 min of ischemia in the animals treated with 10 or 20 mg/kg propentofylline. Partial metabolic recovery occurred even after 30 min of ischemia and 20 mg/kg propentofylline. The recovery of energy metabolism correlated closely with the recovery of neurological functions after ischemia and 4 days of survival.
研究了丙戊茶碱对脊髓缺血再灌注后代谢和功能恢复的影响。通过结扎左肾动脉下方的腹主动脉20或30分钟诱导缺血。再灌注后立即静脉注射丙戊茶碱（1、5、10和20mg/kg），动物恢复4天。1mg/kg和5mg/kg剂量的丙戊茶碱对脊髓能量代谢恢复和后肢神经功能恢复仅有轻微影响。然而，在接受10或20mg/kg丙戊茶碱治疗的动物中，缺血20分钟后腺嘌呤核苷酸、乳酸和葡萄糖几乎完全恢复。即使在缺血30分钟和使用20mg/kg丙戊茶碱后，也出现了部分代谢恢复。缺血后4天存活期间，能量代谢的恢复与神经功能的恢复密切相关。
