Danielisova V, Marsala M, Chavko M, Marsala J
Institute of Neurobiology, Slovak Academy of Sciences, Kosice.
Neurology. 1990 Jul;40(7):1125-9. doi: 10.1212/wnl.40.7.1125.
We studied the effect of graded postischemic reoxygenation on the tissue concentrations of adenylates, glucose, and lactate in the rabbit lumbar spinal cord after 10, 20, and 30 minutes of ischemia. In comparison with recirculation without manipulated PaO2, a decrease of PaO2 to 40 to 45 mm Hg upon reestablishment of blood circulation after ischemia led to an amelioration of the energy metabolism in the spinal cord tissue as determined by measuring the ATP concentration and energy charge. The protective effect of postischemic hypoxia was also reflected by the improvement of neurologic functions in animals after 10 and 20 minutes of ischemia.
我们研究了分级缺血后复氧对兔腰段脊髓在缺血10、20和30分钟后腺苷酸、葡萄糖和乳酸组织浓度的影响。与未控制PaO₂的再灌注相比，缺血后恢复血液循环时将PaO₂降至40至45 mmHg，通过测量ATP浓度和能荷来确定，这导致脊髓组织能量代谢得到改善。缺血后低氧的保护作用还体现在缺血10和20分钟后动物神经功能的改善上。
