Padma M V, Behari M, Misra N K, Ahuja G K
Department of Neurology, All India Institute of Medical Sciences, New Delhi.
Neurology. 1994 Jul;44(7):1344-6. doi: 10.1212/wnl.44.7.1344.
Single, small, enhancing lesions that often resolve spontaneously are frequent findings on CTs of Indian patients with seizures. Based on ELISA and biopsy data, the majority of these lesions are probably cysticercosis. To determine if these patients should be treated with albendazole, we performed a double-blind, randomized, placebo-controlled study involving 75 patients with seizures and the appropriate CT abnormality without neurologic abnormality on examination. Patients were randomized to albendazole (15 mg/kg/d) and placebo for 1 week, and we obtained serial CTs at the end of 1 week, 1 month, and 3 months. All patients completed a 3-month follow-up and none had systemic evidence of tuberculosis or cysticercosis. The lesions varied in size from 3 mm to 2.1 cm, with an average size of 1.18 cm. Serum ELISA for cysticercosis was positive in 30 and CSF ELISA was positive in 20 of 45 patients. Forty patients received albendazole and 35 received placebo. At the end of 3 months, a total of 68 patients showed resolution. Thirty-five of 40 patients who received albendazole showed resolution, as opposed to 33 of 35 patients on placebo. We conclude that albendazole therapy was not beneficial.
在患有癫痫的印度患者的CT检查中，经常发现单个、小的、有强化的病变，且这些病变常可自发消退。根据酶联免疫吸附测定（ELISA）和活检数据，这些病变大多数可能是囊尾蚴病。为了确定这些患者是否应该接受阿苯达唑治疗，我们进行了一项双盲、随机、安慰剂对照研究，涉及75例有癫痫发作且CT有相应异常但检查时无神经学异常的患者。患者被随机分为阿苯达唑组（15mg/kg/天）和安慰剂组，为期1周，我们在1周末、1个月和3个月末获取了系列CT图像。所有患者均完成了3个月的随访，且均无结核病或囊尾蚴病的全身证据。病变大小从3mm到2.1cm不等，平均大小为1.18cm。45例患者中，30例血清囊尾蚴病ELISA呈阳性，20例脑脊液ELISA呈阳性。40例患者接受阿苯达唑治疗，35例接受安慰剂治疗。在3个月末，共有68例患者的病变消退。接受阿苯达唑治疗的40例患者中有35例病变消退，而接受安慰剂治疗的35例患者中有33例病变消退。我们得出结论，阿苯达唑治疗并无益处。
