Heininger U, Stehr K, Schmitt-Grohé S, Lorenz C, Rost R, Christenson P D, Uberall M, Cherry J D
Universitätsklinik für Kinder und Jugendliche, Erlangen, Germany.
Pediatr Infect Dis J. 1994 Apr;13(4):306-9. doi: 10.1097/00006454-199404000-00011.
In conjunction with a pertussis vaccine efficacy trial in Germany, nasopharyngeal specimens were collected from May, 1992, to March, 1993, from patients with cough illnesses. Clinical data were obtained by initial and follow-up questionnaires. Bordetella parapertussis was isolated from 38 patients (mean age, 3.5 years; 68% girls). Clinical characteristics in these cases were compared with those of 76 patients (matched by age and sex) with illness caused by Bordetella pertussis during the same period. Findings were: (B. pertussis/B. parapertussis): cough > 4 weeks 57%/37% (P = 0.06); whoop 80%/59% (P = 0.07); whoop > 2 weeks 26%/18% (P = 0.05); paroxysms 90%/83% (P = 0.5); body temperature > or = 38 degrees C 9%/0% (P = 0.17); vomiting 47%/42% (P = 0.69); and mean leukocyte and lymphocyte counts 12,500/mm3 and 7600/mm3 (P < 0.0001) and 7800/mm3 and 3500/mm3 (P < 0.0001), respectively. Illness caused by B. parapertussis was typical of pertussis but less severe than that caused by B. pertussis. In contrast with B. pertussis infection, lymphocytosis is not a characteristic of B. parapertussis infection. This is most likely a result of the lack of production of lymphocytosis-promoting factor toxin by B. parapertussis.
在德国进行的一项百日咳疫苗效力试验中，于1992年5月至1993年3月从咳嗽疾病患者中采集了鼻咽标本。通过初始问卷和随访问卷获取临床数据。从38例患者（平均年龄3.5岁；68%为女孩）中分离出副百日咳博德特菌。将这些病例的临床特征与同期76例（按年龄和性别匹配）由百日咳博德特菌引起疾病的患者的临床特征进行比较。结果如下：（百日咳博德特菌/副百日咳博德特菌）：咳嗽超过4周57%/37%（P = 0.06）；哮吼80%/59%（P = 0.07）；哮吼超过2周26%/18%（P = 0.05）；阵咳90%/83%（P = 0.5）；体温≥38℃9%/0%（P = 0.17）；呕吐47%/42%（P = 0.69）；平均白细胞计数和淋巴细胞计数分别为12,500/mm³和7600/mm³（P < 0.0001）以及7800/mm³和3500/mm³（P < 0.0001）。副百日咳博德特菌引起的疾病具有百日咳的典型特征，但比百日咳博德特菌引起的疾病症状轻。与百日咳博德特菌感染不同，淋巴细胞增多不是副百日咳博德特菌感染的特征。这很可能是由于副百日咳博德特菌不产生促进淋巴细胞增多的毒素所致。
