Miller L A, Hoffman R E, Barón A E, Marine W M, Melinkovich P
University of Colorado Health Sciences Center, Department of Preventive Medicine and Biometrics, Denver.
Pediatrics. 1994 Aug;94(2 Pt 1):213-9.
A case-control study in which subjects had (controls) or had not (cases) received measles, mumps, and rubella vaccine (MMR) by 2 years of age. Parents of subjects were also surveyed to find out whether they thought selected proposals to improve immunization rates would be successful.
Maternal education of high school or less at the time of the child's birth, more than or equal to two moves between birth and age 2, maternal age < 21 years of age at the time of the child's birth, more than or equal to two older siblings, participation in The Special Supplemental Food Program for Women, Infants, and Children (WIC), participation in the federal food stamp program, and incorrect knowledge of the recommended age for MMR significantly elevated the odds ratio (OR) for delayed immunization. At least two older siblings (OR = 3.2), maternal age < 21 years of age at the time of the child's birth (OR = 2.8), and incorrect knowledge of the recommended age for MMR (OR = 2.7) remained significant risk factors in a multivariate logistic regression model. Insurance status and cost factors were not significant risk factors for delayed immunization. Parents though that reminders for immunization and a central record system would have made obtaining immunizations easier.
Based on our findings of the importance of immunization knowledge and demographic characteristics as risk factors for delayed immunization, we suggest that a message (the recommended age for immunizations) and a target group for that message (families who move frequently, have older children, and are headed by younger parents) be evaluated as an intervention to improve immunization rates.
1)研究儿童麻疹、腮腺炎和风疹疫苗延迟接种的一系列潜在风险因素;2)确定家长对针对儿童疫苗延迟接种问题所提出解决方案的反应。
一项病例对照研究,研究对象为2岁时已接种(对照组)或未接种(病例组)麻疹、腮腺炎和风疹疫苗(MMR)的儿童。同时对研究对象的家长进行调查,了解他们认为某些提高疫苗接种率的提议是否会成功。
孩子出生时母亲受教育程度为高中及以下、出生至2岁期间搬家两次及以上、孩子出生时母亲年龄小于21岁、有两个及以上哥哥姐姐、参与妇女、婴儿和儿童特别补充食品计划(WIC)、参与联邦食品券计划以及对MMR推荐接种年龄的错误认知,均显著提高了延迟接种的比值比(OR)。在多因素逻辑回归模型中,至少两个哥哥姐姐(OR = 3.2)、孩子出生时母亲年龄小于21岁(OR = 2.8)以及对MMR推荐接种年龄的错误认知(OR = 2.7)仍是显著的风险因素。保险状况和费用因素并非延迟接种的显著风险因素。家长们认为免疫接种提醒和中央记录系统会使接种疫苗更加便捷。
基于我们发现免疫接种知识和人口统计学特征作为延迟接种风险因素的重要性,我们建议将一条信息(免疫接种的推荐年龄)及其目标群体(频繁搬家、有大龄儿童且由年轻父母当家的家庭)作为一种干预措施进行评估,以提高疫苗接种率。