Tsypin A B, Nasonova V A, Vedernikova L A, Solov'ev S K, Velikaia M V, Chiklikchi A S, Sazhina E G
Ter Arkh. 1993;65(5):61-5.
Twenty patients suffering from severe systemic lupus erythematosus (SLE) underwent 52 sessions of splenoperfusion (SP) by means of extracorporeal perfusion of the patient's blood through isolated porcine spleen. It got prepared directly before the perfusion. The organ was obtained from a healthy animal in sterile conditions, washed from the blood after cannulation of the artery and vein. The patient's blood was pumped from the peripheral vein to the spleen artery. After passing through the splenic vascular bed the blood outflew from the spleen vein into the opposite peripheral vein of the patient. SP was followed by positive clinical changes: normalization of body temperature, regression of skin symptoms and articular syndrome, reduction of lymphadenopathy, hepato- and splenomegaly. The tests indicated inhibition of SLE activity. Sp-related immunocorrective effect was also present as shown by depression of B-cell hyperreactivity and T-cell immunity stimulation. 1-4-year follow-up of 19 patients showed them to be in remission. The data obtained favour SP inclusion into intensive therapy of severe SLE.
20例重症系统性红斑狼疮（SLE）患者通过将患者血液经分离的猪脾脏进行体外灌注，接受了52次脾灌注（SP）治疗。脾脏在灌注前直接制备。该器官在无菌条件下取自健康动物，在动脉和静脉插管后冲洗掉血液。患者的血液从外周静脉泵入脾动脉。血液通过脾血管床后从脾静脉流出进入患者对侧的外周静脉。脾灌注后出现了积极的临床变化：体温恢复正常、皮肤症状和关节综合征消退、淋巴结病减轻、肝脾肿大减轻。检测表明SLE活动受到抑制。如B细胞高反应性降低和T细胞免疫刺激所示，还存在与脾相关的免疫纠正作用。对19例患者进行的1至4年随访显示他们处于缓解期。所获得的数据支持将脾灌注纳入重症SLE的强化治疗。
