对皮内甲型肝炎疫苗反应不足。

Inadequate response to intradermal hepatitis A vaccine.

作者信息

Brindle R J, Morris C A, Berger R, Kurtz J B

机构信息

Virology Department, John Radcliffe Hospital, Oxford, UK.

出版信息

Vaccine. 1994 May;12(6):483-4. doi: 10.1016/0264-410x(94)90303-4.

DOI:10.1016/0264-410x(94)90303-4

PMID:8036820

Abstract

To assess the efficacy of the intradermal route of administration of hepatitis A vaccine we conducted a study in hospital laboratory workers. Forty-three volunteers were given three different combinations of intradermal and intramuscular hepatitis A vaccine and compared with 18 controls given intramuscular vaccine only. The geometric mean titres (GMT) after one, two and three intradermal doses of 0.1 ml each were 4.5, 28 and 143 IU l-1 respectively. The GMT after one intramuscular dose in the controls was 163 IU l-1. The results indicate that the response to intradermal hepatitis A vaccine is poor and its use cannot be recommended.

摘要

为评估甲型肝炎疫苗皮内注射途径的效果，我们对医院实验室工作人员进行了一项研究。43名志愿者接种了三种不同组合的皮内和肌内甲型肝炎疫苗，并与18名仅接种肌内疫苗的对照者进行比较。每次皮内注射0.1毫升，注射一、二、三次后的几何平均滴度（GMT）分别为4.5、28和143 IU l-1。对照组单次肌内注射后的GMT为163 IU l-1。结果表明，对皮内甲型肝炎疫苗的反应较差，不建议使用。