• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

MAP kinases ERK1 and ERK2: pleiotropic enzymes in a ubiquitous signaling network.

作者信息

Robbins D J, Zhen E, Cheng M, Xu S, Ebert D, Cobb M H

机构信息

University of Texas Southwestern Medical Center, Department of Pharmacology, Dallas 75235.

出版信息

Adv Cancer Res. 1994;63:93-116. doi: 10.1016/s0065-230x(08)60399-1.

DOI:10.1016/s0065-230x(08)60399-1
PMID:8036991
Abstract
摘要

相似文献

1
MAP kinases ERK1 and ERK2: pleiotropic enzymes in a ubiquitous signaling network.丝裂原活化蛋白激酶ERK1和ERK2:普遍存在的信号网络中的多效性酶
Adv Cancer Res. 1994;63:93-116. doi: 10.1016/s0065-230x(08)60399-1.
2
The mitogen-activated protein kinases, ERK1 and ERK2.
Semin Cancer Biol. 1994 Aug;5(4):261-8.
3
Mitogen-activated protein kinase activation during IgG-dependent phagocytosis in human neutrophils: inhibition by ceramide.人中性粒细胞中IgG依赖的吞噬作用过程中丝裂原活化蛋白激酶的激活:神经酰胺的抑制作用
J Immunol. 1997 May 15;158(10):4961-7.
4
Immune complex kinase assays for mitogen-activated protein kinase and MEK.用于丝裂原活化蛋白激酶和丝裂原活化蛋白激酶激酶的免疫复合物激酶分析
Methods Enzymol. 1995;255:245-56. doi: 10.1016/s0076-6879(95)55027-5.
5
The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation.Ras激酶抑制因子(KSR)通过使Elk-1磷酸化与丝裂原活化蛋白激酶(MAP激酶)激活解偶联来调节生长因子和Ras信号传导。
EMBO J. 1998 Mar 16;17(6):1717-27. doi: 10.1093/emboj/17.6.1717.
6
Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation.
Leukemia. 1999 Apr;13(4):585-9. doi: 10.1038/sj.leu.2401369.
7
Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2).核因子-κB的缺氧激活由Ras和Raf信号通路介导,且不涉及丝裂原活化蛋白激酶(ERK1或ERK2)。
Cancer Res. 1994 Oct 15;54(20):5273-9.
8
Structural analysis of the MAP kinase ERK2 and studies of MAP kinase regulatory pathways.
Adv Pharmacol. 1996;36:49-65. doi: 10.1016/s1054-3589(08)60576-1.
9
Ras/MAP kinase-dependent and -independent signaling pathways target distinct ternary complex factors.Ras/丝裂原活化蛋白激酶依赖性和非依赖性信号通路靶向不同的三元复合因子。
Genes Dev. 1994 Aug 1;8(15):1803-16. doi: 10.1101/gad.8.15.1803.
10
Mitogen-activated protein kinase acts as a negative regulator of the heat shock response in NIH3T3 cells.丝裂原活化蛋白激酶在NIH3T3细胞中作为热休克反应的负调节因子发挥作用。
Cancer Res. 1995 Dec 1;55(23):5512-9.

引用本文的文献

1
Rasal1 regulates calcium dependent neuronal maturation by modifying microtubule dynamics.Rasal1通过改变微管动力学来调节钙依赖性神经元成熟。
Cell Biosci. 2024 Jan 21;14(1):13. doi: 10.1186/s13578-024-01193-w.
2
Contributions of extracellular-signal regulated kinase 1/2 activity to the memory trace.细胞外信号调节激酶1/2活性对记忆痕迹的作用。
Front Mol Neurosci. 2022 Oct 5;15:988790. doi: 10.3389/fnmol.2022.988790. eCollection 2022.
3
DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation.
DUSP6 的 SUMOylation 通过直接调控 Drp1 的去磷酸化来保护细胞免受氧化损伤。
Sci Adv. 2020 Mar 25;6(13):eaaz0361. doi: 10.1126/sciadv.aaz0361. eCollection 2020 Mar.
4
Regulatory activity of polyunsaturated fatty acids in T-cell signaling.多不饱和脂肪酸在T细胞信号传导中的调节活性。
Prog Lipid Res. 2010 Jul;49(3):250-61. doi: 10.1016/j.plipres.2010.01.002. Epub 2010 Feb 20.
5
In vitro and in vivo metabolism of the anti-cancer agent CI-1040, a MEK inhibitor, in rat, monkey, and human.抗癌药物CI-1040(一种MEK抑制剂)在大鼠、猴和人体内的体外及体内代谢情况。
Pharm Res. 2004 Sep;21(9):1670-9. doi: 10.1023/b:pham.0000041464.27579.d0.
6
Eicosapentaenoic acid and docosahexaenoic acid modulate MAP kinase enzyme activity in human T-cells.二十碳五烯酸和二十二碳六烯酸调节人T细胞中的丝裂原活化蛋白激酶(MAP激酶)酶活性。
Mol Cell Biochem. 2002 Mar;232(1-2):143-8. doi: 10.1023/a:1014806122510.
7
Active erk regulates microtubule stability in H-ras-transformed cells.活性细胞外调节蛋白激酶在H-ras转化细胞中调节微管稳定性。
Neoplasia. 2001 Sep-Oct;3(5):385-94. doi: 10.1038/sj.neo.7900180.
8
Signal transduction by epidermal growth factor and heregulin via the kinase-deficient ErbB3 protein.表皮生长因子和神经调节蛋白通过激酶缺陷型ErbB3蛋白进行信号转导。
Biochem J. 1998 Aug 15;334 ( Pt 1)(Pt 1):189-95. doi: 10.1042/bj3340189.
9
Opioid modulation of extracellular signal-regulated protein kinase activity is ras-dependent and involves Gbetagamma subunits.阿片类物质对细胞外信号调节蛋白激酶活性的调节依赖于Ras,且涉及Gβγ亚基。
J Neurochem. 1998 Feb;70(2):635-45. doi: 10.1046/j.1471-4159.1998.70020635.x.
10
Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK.Jun氨基末端激酶/应激激活蛋白激酶(JNK/SAPK)是脂多糖刺激肿瘤坏死因子α(TNF-α)翻译所必需的:糖皮质激素通过阻断JNK/SAPK来抑制TNF-α的翻译。
Mol Cell Biol. 1997 Nov;17(11):6274-82. doi: 10.1128/MCB.17.11.6274.