Koenigsberg H W, Pollak C P, Fine J, Kakuma T
Department of Psychiatry, Cornell University Medical College, White Plains, NY.
Am J Psychiatry. 1994 Aug;151(8):1148-52. doi: 10.1176/ajp.151.8.1148.
This study examined cardiac and respiratory activity in panic disorder patients and healthy comparison subjects during sleep, when the effects of anxious cognition and expectancy set are minimized.
Heart rate, respiratory rate, end-tidal PCO2, and oxygen saturation were recorded for 11 panic disorder patients and 12 comparison subjects before and during sleep and before and after infusions of sodium lactate and a saline control.
Panic disorder patients had higher oxygen saturations than comparison subjects before sleep onset and during sleep stages 0 and 2 before any infusions. The two groups did not differ on other respiratory variables and heart rate. Panic disorder patients responded to lactate infusions during stage 3-4 sleep with greater increases in heart rate and oxygen saturation, and possibly in respiratory rate and end-tidal PCO2, than comparison subjects. The saline control infusion had little effect.
These findings suggest that panic disorder patients have greater cardiac and respiratory reactivity than healthy comparison subjects during sleep, when the influence of cognitive factors is minimal or absent.
本研究在睡眠期间对惊恐障碍患者和健康对照者的心脏和呼吸活动进行了检查，此时焦虑认知和预期设定的影响被最小化。
记录了11名惊恐障碍患者和12名对照者在睡眠前、睡眠期间以及输注乳酸钠和生理盐水对照前后的心率、呼吸频率、呼气末二氧化碳分压和血氧饱和度。
在任何输注之前，惊恐障碍患者在睡眠开始前以及睡眠第0和第2阶段的血氧饱和度均高于对照者。两组在其他呼吸变量和心率方面没有差异。与对照者相比，惊恐障碍患者在第3-4阶段睡眠期间对乳酸输注的反应是心率和血氧饱和度增加更大，呼吸频率和呼气末二氧化碳分压可能也增加。生理盐水对照输注几乎没有影响。
这些发现表明，在认知因素影响最小或不存在的睡眠期间，惊恐障碍患者比健康对照者具有更大的心脏和呼吸反应性。
