Yeragani V K, Srinivasan K, Balon R, Ramesh C, Berchou R
Department of Psychiatry, Wayne State University School of Medicine, Detroit, Mich.
Am J Psychiatry. 1994 Aug;151(8):1226-8. doi: 10.1176/ajp.151.8.1226.
Using spectral analysis of the continuous time series signal before and during lactate and placebo infusions, the authors studied heart rate variability in six patients with panic disorder and nine normal comparison subjects. The decrease in high-frequency (0.20-0.50 Hz) power and the increase in sympathovagal ratios (mid-frequency [0.07-0.15 Hz] to high-frequency powers) after the administration of intravenous sodium lactate were significantly greater in the patients than in the normal subjects after correction of the values for the amount of lactate infused. This result suggests an exaggerated cardiac vagal withdrawal in patients with panic disorder during lactate infusions.
通过对乳酸盐和安慰剂输注前及输注过程中连续时间序列信号进行频谱分析，作者研究了6名惊恐障碍患者和9名正常对照受试者的心率变异性。静脉注射乳酸钠后，患者高频（0.20 - 0.50赫兹）功率的降低以及交感迷走神经比率（中频[0.07 - 0.15赫兹]与高频功率之比）的增加，在根据输注的乳酸盐量校正数值后，显著大于正常受试者。这一结果表明，惊恐障碍患者在输注乳酸盐期间心脏迷走神经的撤离过度。
