肌肉注射金疗法对类风湿关节炎患者幽门螺杆菌感染血清学参数无影响：一项为期12个月的前瞻性研究。
No effect of intramuscular gold therapy on serological parameters of Helicobacter pylori infection in patients with rheumatoid arthritis: a 12 month prospective study.
作者信息
ten Wolde S, Janssen M, van Duijn W, Lamers C B, Hermans J, Dijkmans B A
机构信息
Department of Rheumatology, University Hospital Leiden, The Netherlands.
出版信息
Ann Rheum Dis. 1994 Jun;53(6):400-2. doi: 10.1136/ard.53.6.400.
OBJECTIVES
To assess prospectively the influence of intramuscular gold therapy on Helicobacter pylori serology in patients with rheumatoid arthritis (RA).
METHODS
Fifty patients with RA were started on intramuscular gold or chloroquine, as the control group and were followed serologically for H pylori infection for 12 months.
RESULTS
Twelve patients treated with gold and eight control patients treated with chloroquine, all with serological evidence for H pylori infection, showed no significant decline of IgA and IgG anti-H pylori antibody levels or serum pepsinogen A and C levels. Total serum IgA and IgG levels declined significantly during gold therapy, while they remained unchanged during chloroquine therapy.
CONCLUSIONS
Intramuscular gold therapy in patients with RA does not influence the serological parameters of H pylori infection.
目的
前瞻性评估肌肉注射金制剂疗法对类风湿关节炎（RA）患者幽门螺杆菌血清学的影响。
方法
50例RA患者开始接受肌肉注射金制剂或氯喹治疗，氯喹治疗组作为对照组，对两组患者进行为期12个月的幽门螺杆菌感染血清学随访。
结果
接受金制剂治疗的12例患者和接受氯喹治疗的8例对照患者，所有患者均有幽门螺杆菌感染的血清学证据，其IgA和IgG抗幽门螺杆菌抗体水平以及血清胃蛋白酶原A和C水平均无显著下降。在金制剂治疗期间，血清总IgA和IgG水平显著下降，而在氯喹治疗期间则保持不变。
结论
RA患者接受肌肉注射金制剂治疗不会影响幽门螺杆菌感染的血清学参数。
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