Jaskowski T D, Martins T B, Hill H R, Litwin C M
Associated Regional and University Pathologists Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108, USA.
J Clin Microbiol. 1997 Nov;35(11):2999-3000. doi: 10.1128/jcm.35.11.2999-3000.1997.
Serological testing for immunoglobulin G (IgG) antibodies to Helicobacter pylori has proven useful in supporting the diagnosis of infection with this organism, but the clinical value of IgA antibodies in H. pylori-related gastritis remains controversial. The purpose of our study was to determine the frequency of IgA-positive IgG-negative patients with symptoms of gastrointestinal (GI) disorders, thus assessing the clinical utility of IgA testing for H. pylori-related gastritis. It was found previously that the frequency of infected individuals in this category (IgA positive and IgG negative) is about 2%, but a large number of IgG-negative patients with GI disorders suggestive of H. pylori infection have not been investigated until now.
针对幽门螺杆菌的免疫球蛋白G（IgG）抗体进行血清学检测已被证明有助于支持该病原体感染的诊断，但IgA抗体在幽门螺杆菌相关性胃炎中的临床价值仍存在争议。我们研究的目的是确定有胃肠道（GI）疾病症状的IgA阳性IgG阴性患者的比例，从而评估IgA检测在幽门螺杆菌相关性胃炎中的临床实用性。此前发现，这一类别（IgA阳性且IgG阴性）的感染个体比例约为2%，但到目前为止，大量提示幽门螺杆菌感染的胃肠道疾病IgG阴性患者尚未得到研究。
