Biasco G, Paganelli G M, Vaira D, Holton J, Di Febo G, Brillanti S, Miglioli M, Barbara L, Samloff I M
First Medical Clinic, University of Bologna, Italy.
J Clin Pathol. 1993 Sep;46(9):826-8. doi: 10.1136/jcp.46.9.826.
To investigate the association between histologically confirmed gastritis, carriage of Helicobacter pylori and pepsinogen (PG) I and PG II concentrations.
Prospective study of 81 dyspeptic patients undergoing upper gastrointestinal endoscopy was made. The extent of gastric mucosal inflammation and the presence of H pylori was determined, and serology to evaluate PG I and II concentrations and IgG titres to H pylori was carried out.
The presence of H pylori was strongly correlated with high IgG antibody titres to H pylori and gastritis. Patients who were H pylori positive had significantly higher PG I and PG II concentrations and a significantly lower PG I:PG II ratio than patients who were negative for H pylori. In 13 patients with duodenal ulcer and H pylori positive gastritis serum PG I concentrations were significantly higher than in H pylori positive patients without duodenal ulcer. Significant correlations were found between the age of patients and serum PG II, the PG I:PG II ratio, IgG antibodies to H pylori, the severity of body gastritis and H pylori infection, and between the degree of gastritis in the body of the stomach and the PG II concentration.
Serum PG I and II concentrations, together with a fall in the PG I:PG II ratio, could be used as predictors of H pylori infection as well as serum IgG antibody response to H pylori.
研究经组织学确诊的胃炎、幽门螺杆菌感染与胃蛋白酶原（PG）I和PG II浓度之间的关联。
对81例接受上消化道内镜检查的消化不良患者进行前瞻性研究。确定胃黏膜炎症程度和幽门螺杆菌的存在情况，并进行血清学检测以评估PG I和PG II浓度以及幽门螺杆菌IgG滴度。
幽门螺杆菌的存在与幽门螺杆菌高IgG抗体滴度及胃炎密切相关。幽门螺杆菌阳性患者的PG I和PG II浓度显著高于幽门螺杆菌阴性患者，且PG I:PG II比值显著低于后者。在13例十二指肠溃疡且幽门螺杆菌阳性胃炎患者中，血清PG I浓度显著高于无十二指肠溃疡的幽门螺杆菌阳性患者。患者年龄与血清PG II、PG I:PG II比值、幽门螺杆菌IgG抗体、胃体部胃炎严重程度及幽门螺杆菌感染之间，以及胃体部胃炎程度与PG II浓度之间均存在显著相关性。
血清PG I和PG II浓度以及PG I:PG II比值的下降可作为幽门螺杆菌感染以及血清对幽门螺杆菌IgG抗体反应的预测指标。
