Tadjkarimi S, Chester A H, Borland J A, Schyns C J, O'Neil G S, Yacoub M H
Department of Surgery, National Heart & Lung Institute, Harefield Hospital, Middlesex, United Kingdom.
Ann Thorac Surg. 1994 Jul;58(1):207-10. doi: 10.1016/0003-4975(94)91101-0.
In the inferior epigastric artery, endothelium-dependent relaxations in response to substance P, histamine, and acetylcholine were present. These were greater than reported values in saphenous veins but less than the documented responses in internal mammary and gastroepiploic arteries. Endothelium-independent stimulation with nifedipine, papaverine, sodium nitroprusside, and glyceryl trinitrate induced relaxations that also were reduced compared with established arterial conduits. These findings appear to justify the clinical use of the inferior epigastric artery as a coronary bypass graft with monitoring of its long-term results and possibly perioperative pharmacologic manipulations.
在腹壁下动脉中，对P物质、组胺和乙酰胆碱的内皮依赖性舒张反应存在。这些反应大于隐静脉中报道的值，但小于乳内动脉和胃网膜动脉中记录的反应。用硝苯地平、罂粟碱、硝普钠和硝酸甘油进行的非内皮依赖性刺激诱导的舒张反应与已建立的动脉管道相比也有所降低。这些发现似乎证明了腹壁下动脉作为冠状动脉旁路移植术临床应用的合理性，同时需要监测其长期结果，并可能进行围手术期药物干预。
