Mügge A, Barton M R, Cremer J, Frombach R, Lichtlen P R
Division of Cardiology, Hannover Medical School, Germany.
Ann Thorac Surg. 1993 Nov;56(5):1085-9. doi: 10.1016/0003-4975(95)90020-9.
Vascular responses to endogenous agonists may determine patency rates of bypass graft conduits. The effect of constrictors (noradrenaline, phenylephrine, serotonin, histamine, angiotensin II) and dilators (acetylcholine, substance P, bradykinin, nitroglycerin) were compared in human internal mammary and inferior epigastric arteries in vitro. The latter vessel type has been recently advocated as an additional conduit for coronary artery bypass grafting. Whereas the alpha-adrenoceptor- (noradrenaline, phenylephrine) and serotonin receptor-mediated contractions were similar in both vessels, histamine-induced contractions were greatly enhanced in internal mammary arteries (maximal responses in percent of 80 mmol/L KCl, 131% +/- 15% versus 59% +/- 8%). Maximal contractions in response to angiotensin II were greater in inferior epigastric arteries (50% +/- 6% versus 25% +/- 5%). The endothelium-independent relaxations in response to nitroglycerin were identical in both vessels. In contrast, the endothelium-dependent relaxations in response to acetylcholine, substance P, and bradykinin were significantly greater in the inferior epigastric than in the internal mammary arteries (maximal relaxations expressed as percent of prostaglandin F2 alpha-induced precontraction: acetylcholine, 94% +/- 5% versus 77% +/- 5%; substance P, 85% +/- 4% versus 24% +/- 5%; bradykinin, 77% +/- 5% versus 26% +/- 3%). It is concluded that the inferior epigastric artery has a high endothelial capacity to release endothelium-derived relaxing factor. It appears that the inferior epigastric artery possesses credentials to be successfully used for coronary artery bypass grafting.
血管对内源性激动剂的反应可能决定旁路移植管道的通畅率。在体外对人乳内动脉和腹壁下动脉中收缩剂（去甲肾上腺素、去氧肾上腺素、5-羟色胺、组胺、血管紧张素II）和扩张剂（乙酰胆碱、P物质、缓激肽、硝酸甘油）的作用进行了比较。后一种血管类型最近被推荐作为冠状动脉旁路移植的额外管道。虽然α-肾上腺素能受体介导的收缩（去甲肾上腺素、去氧肾上腺素）和5-羟色胺受体介导的收缩在两种血管中相似，但组胺诱导的收缩在乳内动脉中大大增强（以80 mmol/L氯化钾收缩反应的百分比表示最大反应，分别为131%±15%和59%±8%）。对血管紧张素II的最大收缩反应在腹壁下动脉中更大（分别为50%±6%和25%±5%）。对硝酸甘油的非内皮依赖性舒张在两种血管中相同。相反，对乙酰胆碱、P物质和缓激肽的内皮依赖性舒张在腹壁下动脉中明显大于乳内动脉（最大舒张以前列腺素F2α诱导的预收缩百分比表示：乙酰胆碱，分别为94%±5%和77%±5%；P物质，分别为85%±4%和24%±5%；缓激肽，分别为77%±5%和26%±3%）。结论是腹壁下动脉具有高内皮能力释放内皮源性舒张因子。看来腹壁下动脉有资格成功用于冠状动脉旁路移植。
