Rudy J W, Morledge P
Department of Psychology, University of Colorado, Boulder 80309-0345.
Behav Neurosci. 1994 Apr;108(2):227-34. doi: 10.1037//0735-7044.108.2.227.
The authors present developmental evidence that contextual fear conditioning is supported by a short-term memory system that supports conditioning immediately after a shock and by a long-term memory system that supports contextual conditioning 24 hr after training. This is based on the finding that after 1 conditioning trial, rats 18 to 32 days old show the same amount of conditioned freezing when tested immediately after conditioning but 18-day-old rats show much less conditioned freezing than the older rats when the retention interval is 24 hr. The data also suggest that the long-term memory representation of context that mediates conditioned fear is not available until several hours after the conditioning trial. Implications of these findings for memory consolidation processes, infantile amnesia, and hippocampal formation development are discussed.
作者提供了发育方面的证据，表明情境恐惧条件反射由一个短期记忆系统支持，该系统在电击后立即支持条件反射，还由一个长期记忆系统支持，该系统在训练后24小时支持情境条件反射。这是基于以下发现：在进行一次条件反射试验后，18至32日龄的大鼠在条件反射后立即测试时表现出相同程度的条件性僵立，但当保持间隔为24小时时，18日龄的大鼠表现出的条件性僵立比年长的大鼠少得多。数据还表明，介导条件性恐惧的情境的长期记忆表征在条件反射试验后数小时才会形成。文中讨论了这些发现对记忆巩固过程、婴儿期遗忘症和海马结构发育的影响。
