Avery P, Hudson N, Hubner P
Regional Cardiac Unit, Groby Road Hospital, Leicester.
Br Heart J. 1993 Jul;70(1):22-6. doi: 10.1136/hrt.70.1.22.
To investigate the ability of gated methoxy-isobutylisonitrile (MIBI) scintigraphy to measure changes in myocardial function as well as perfusion with exercise.
Regional cardiothoracic centre.
43 presenting with chest pain, 28 with coronary artery disease on angiography, and 15 with normal coronary arteriograms.
Gated perfusion images showed an improvement in detecting regions with stenosed arteries compared with non-gated images (38/55 v 31/55, p < or = 0.01)). Functional analysis showed an increase in fractional shortening of 4.11% in subjects with normal coronary arteries, whereas in those with coronary disease a fall of 0.57% was found (p < or = 0.01). Both perfusion and function imaging showed an improved sensitivity compared with standard exercise testing (p < or = 0.01). When both function and perfusion imaging were analysed all patients with coronary disease were detected. There was agreement in abnormal regions in 33/55 territories supplied by a stenosed artery. Combined perfusion and function detected 49/55 (89%) of abnormal regions, thus improving the overall sensitivity from 38/55 (69%) by perfusion imaging alone (p < or = 0.01).
Gated methoxy-isobutylisonitrile scintigraphy can successfully evaluate perfusion and function on exercise, so improving the diagnostic usefulness of this agent.
研究门控甲氧基异丁基异腈（MIBI）心肌灌注显像测量运动时心肌功能及灌注变化的能力。
地区性心胸中心。
43例胸痛患者，28例血管造影显示有冠状动脉疾病，15例冠状动脉造影正常。
与非门控图像相比，门控灌注图像在检测动脉狭窄区域方面有所改善（38/55对31/55，p≤0.01）。功能分析显示，冠状动脉正常的受试者的缩短分数增加了4.11%，而冠状动脉疾病患者的缩短分数下降了0.57%（p≤0.01）。与标准运动试验相比，灌注和功能成像的敏感性均有所提高（p≤0.01）。当对功能和灌注成像进行分析时，所有冠心病患者均被检测出。在由狭窄动脉供血的55个区域中，33个区域的异常区域存在一致性。灌注和功能联合检测出55个异常区域中的49个（89%），从而使整体敏感性从单独灌注成像的38/55（69%）提高（p≤0.01）。
门控甲氧基异丁基异腈心肌灌注显像能够成功评估运动时的灌注和功能，从而提高该药物的诊断价值。
