大肠杆菌和霍乱弧菌的肠毒素对非洲绿猴肾细胞中环磷酸腺苷分泌的刺激作用。
Stimulation of cyclic AMP secretion in Vero cells by enterotoxins of Escherichia coli and Vibrio cholerae.
作者信息
Stavric S, Speirs J I, Konowalchuk J, Jeffrey D
出版信息
Infect Immun. 1978 Aug;21(2):514-7. doi: 10.1128/iai.21.2.514-517.1978.
Abstract
The morphological response of Vero cells to Escherichia coli heat-labile enterotoxin was similar to that of cholera toxin and was accompanied by increases in the intracellular level of cyclic AMP. The effects of both enterotoxins were enhanced by the presence of phosphodiesterase inhibitor and inhibited by heat or specific antisera. Accumulation of cyclic AMP preceded the morphological response.
摘要
Vero细胞对大肠杆菌不耐热肠毒素的形态学反应与霍乱毒素相似，且伴有细胞内环磷酸腺苷（cAMP）水平升高。磷酸二酯酶抑制剂的存在增强了两种肠毒素的作用，而加热或特异性抗血清则抑制了其作用。cAMP的积累先于形态学反应。
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