活动性十二指肠溃疡患者及幽门螺杆菌根除后愈合的十二指肠溃疡患者胃液中的磷脂酶A2活性
Phospholipase A2 activity in gastric juice from patients with active and H. pylori-eradicated healed duodenal ulcer.
作者信息
Berstad K, Sjödahl R, Berstad A
机构信息
Medical Department A, Haukeland University Hospital, University of Bergen, Norway.
出版信息
Aliment Pharmacol Ther. 1994 Apr;8(2):175-80. doi: 10.1111/j.1365-2036.1994.tb00275.x.
BACKGROUND
Despite the close association between gastric Helicobacter pylori infection and duodenal ulcer, little is known about how this organism may promote mucosal damage. A possibility might be that it produces, or induces the host to release, phospholipases that metabolize the protective layer of phospholipids.
METHODS
Aimed at determination of phospholipase A2 activity and the concentration of choline-containing phospholipids in gastric juice, aspirates were collected during gastroscopy in 38 consecutive referrals with either active (n = 19) or H. pylori-eradicated healed duodenal ulcer (n = 19).
RESULTS
Gastric juice phospholipase A2 activity was 3.1 times higher in active than in healed duodenal ulcers (P = 0.03). Concurrently, the concentration of choline-containing phospholipids in the group with active ulcers was less than half compared with the healed group (P = 0.02).
CONCLUSION
The results indicate that phospholipase A2 activity and the concentration of choline-containing phospholipids in gastric juice are related to H. pylori status and duodenal ulcer disease.
背景
尽管胃幽门螺杆菌感染与十二指肠溃疡密切相关，但对于该病原体如何促进黏膜损伤却知之甚少。一种可能性是它产生或诱导宿主释放磷脂酶，这些磷脂酶会代谢磷脂保护层。
方法
为了测定胃液中磷脂酶A2的活性和含胆碱磷脂的浓度，在胃镜检查期间，对38例连续转诊患者进行了胃液抽吸，这些患者患有活动性十二指肠溃疡（n = 19）或幽门螺杆菌根除后的愈合性十二指肠溃疡（n = 19）。
结果
活动性十二指肠溃疡患者的胃液磷脂酶A2活性比愈合性十二指肠溃疡患者高3.1倍（P = 0.03）。同时，活动性溃疡组中含胆碱磷脂的浓度与愈合组相比不到一半（P = 0.02）。
结论
结果表明，胃液中磷脂酶A2的活性和含胆碱磷脂的浓度与幽门螺杆菌状态及十二指肠溃疡病有关。
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