Parasuraman R, Martin A
Cognitive Science Laboratory, Catholic University of America, Washington, DC 20064.
Curr Opin Neurobiol. 1994 Apr;4(2):237-44. doi: 10.1016/0959-4388(94)90079-5.
Alzheimer's disease leads to a selective decline of cognitive skills, particularly semantic knowledge and visuospatial attention. Recent advances suggest that, although the two systems responsible for these skills can interact, the semantic memory deficit seen in Alzheimer's disease cannot be solely attributed to attention or retrieval deficiencies. This is consistent with a modular view of cognition, which postulates that disruption to these systems is selective in Alzheimer's disease. Cortico-cortical disconnection of association areas may disrupt widespread networks mediating attention and semantic knowledge in Alzheimer's disease.
阿尔茨海默病会导致认知技能的选择性衰退，尤其是语义知识和视觉空间注意力。最近的研究进展表明，尽管负责这些技能的两个系统可以相互作用，但在阿尔茨海默病中出现的语义记忆缺陷不能仅仅归因于注意力或检索缺陷。这与认知的模块化观点一致，该观点假定在阿尔茨海默病中对这些系统的破坏是选择性的。联合区域的皮质-皮质断开连接可能会破坏在阿尔茨海默病中介导注意力和语义知识的广泛网络。
