Photoinactivation of bacteriophage lambda by kojic acid and Fe(III): role of oxygen radical intermediates in the reaction.
作者信息
Bhat R, Hadi S M
机构信息
Department of Biochemistry, F/O: Life Sciences, A.M.U. Aligarh (U.P), India.
出版信息
Biochem Mol Biol Int. 1994 Mar;32(4):731-5.
PMID:8038723
Abstract
Kojic acid, a bacterial metabolite, intensively used in food and pharmaceutical industry has been reported to induce strand breaks in double stranded DNA. This genotoxic action of kojic acid was tested directly by using bacteriophage inactivation. The inactivating activity is mediated through DNA strand scissions by oxygen free radical intermediates. This was tested by quenching of the inactivation reaction in presence of radical scavengers. These results indicate the usefulness of a simple system to test various risk factors in dietary components.
摘要
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