Bhat R, Hadi S M
Department of Biochemistry, F/O: Life Sciences, A.M.U. Aligarh (U.P), India.
Biochem Mol Biol Int. 1994 Mar;32(4):731-5.
Kojic acid, a bacterial metabolite, intensively used in food and pharmaceutical industry has been reported to induce strand breaks in double stranded DNA. This genotoxic action of kojic acid was tested directly by using bacteriophage inactivation. The inactivating activity is mediated through DNA strand scissions by oxygen free radical intermediates. This was tested by quenching of the inactivation reaction in presence of radical scavengers. These results indicate the usefulness of a simple system to test various risk factors in dietary components.
曲酸是一种细菌代谢产物，在食品和制药行业中广泛使用，据报道它会导致双链DNA链断裂。通过噬菌体失活直接测试了曲酸的这种遗传毒性作用。失活活性是由氧自由基中间体介导的DNA链断裂所引起的。这通过在自由基清除剂存在下淬灭失活反应来进行测试。这些结果表明了一个简单系统在测试饮食成分中各种风险因素方面的实用性。
