Waterhouse C
Cancer Res. 1975 Apr;35(4):987-90.
GammaG-Globulin and excess light-chain metabolism were studied in eight subjects with progressive metastatic malignant disease by determining the plasma radioactivity curves following the administration of appropriately labeled substances. In addition to the plasma die-away curves, which required about 3 weeks for full expression for gamma-globulin, but only 3 to 4 days for light-chain, urinary excretion of the label from metabolized protein was determined. The data are compared to similar studies in control individuals. The metabolism of excess light chain was similar to normal in all respects. The total synthesis of gammaG-globulin was increased with a mean value about twice normal. The mean survival time of a circulating immunoglobulin molecule was short, indicating rapid loss from the system. Other aspects of immunoglobulin metabolism were similar to normal with a normal percentage of the labeled protein appearing in the urine, suggesting no abnormality in the utilization pattern but simply an increased rate of turnover. The capability of malnourished patients with cancer to produce large quantities of immunoglobulin is not specific for this disease, since similar patterns may be seen in response to infections in protein-depleted individuals. However, there is the possibility that the cancer itself acts as an inciting agent in these subjects. Furthermore, such sustained protein synthesis may place an additional burden on already compromised host metabolism.
通过给予适当标记的物质后测定血浆放射性曲线，对8例进行性转移性恶性疾病患者的γ-球蛋白和过量轻链代谢进行了研究。除了血浆消失曲线外，还测定了代谢蛋白中标记物的尿排泄情况。血浆消失曲线显示，γ-球蛋白完全表达需要约3周时间，而轻链仅需3至4天。将这些数据与对照组个体的类似研究进行了比较。过量轻链的代谢在各方面均与正常情况相似。γG-球蛋白的总合成增加，平均值约为正常的两倍。循环免疫球蛋白分子的平均存活时间较短，表明其从系统中快速丢失。免疫球蛋白代谢的其他方面与正常情况相似，尿中出现的标记蛋白百分比正常，这表明利用模式没有异常，只是周转率增加。癌症营养不良患者产生大量免疫球蛋白的能力并非该疾病所特有，因为在蛋白质缺乏个体对感染的反应中也可能出现类似模式。然而，癌症本身有可能在这些患者中起到诱发作用。此外，这种持续的蛋白质合成可能会给本已受损的宿主代谢带来额外负担。
