Elmståhl S, Rosén I, Gullberg B
Department of Community Health Sciences, University of Lund, Malmö General Hospital, Sweden.
Dementia. 1994 Mar-Apr;5(2):119-24. doi: 10.1159/000106706.
Multichannel (19) EEG were analyzed in 23 female patients with rather advanced late-onset Alzheimer's disease (AD) and compared with 56 age- and sex-matched healthy control subjects. The quantified EEG was correlated with psychometric and clinical variables. The control subjects showed increasing theta activity with age but the EEG changes did not correlate significantly with psychometric features. The AD patients showed highly significant increases in delta and theta activity and decreases in beta activity compared with controls. The EEG changes were most marked over posterior regions of the brain. The individual EEG variables showed a high degree of intercorrelation and an almost complete discrimination between patients and controls was accomplished by taking only the posterior delta activity into account. In a subgroup of 10 patients, in which a Mini Mental test score could be obtained, the score correlated with the relative theta power.
对23名患有相当晚期晚发性阿尔茨海默病（AD）的女性患者进行了多通道（19导）脑电图分析，并与56名年龄和性别匹配的健康对照者进行了比较。对脑电图进行量化，并将其与心理测量和临床变量相关联。对照者的θ活动随年龄增加，但脑电图变化与心理测量特征无显著相关性。与对照组相比，AD患者的δ和θ活动显著增加，β活动减少。脑电图变化在大脑后部区域最为明显。个体脑电图变量显示出高度的相互关联性，仅考虑后部δ活动就能几乎完全区分患者和对照者。在10名能够获得简易精神状态检查分数的患者亚组中，该分数与相对θ功率相关。
