Department of Neurology, Danish Dementia Research Centre (DDRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Norwegian National Advisory Unit on Ageing and Health (Ageing and Health), Vestfold Hospital Trust and Oslo University Hospital, Ullevaal, Oslo, Norway.
J Alzheimers Dis. 2018;64(4):1359-1371. doi: 10.3233/JAD-180300.
Quantitative EEG (qEEG) power could potentially be used as a diagnostic tool for Alzheimer's disease (AD) and may further our understanding of the pathophysiology. However, the early qEEG power changes of AD are not well understood.
To investigate the early changes in qEEG power and the possible correlation with memory function and cerebrospinal fluid biomarkers. In addition, whether qEEG power could discriminate between AD, mild cognitive impairment (MCI), and older healthy controls (HC) at the individual level.
Standard EEGs from 138 HC, 117 MCI, and 117 AD patients were included from six Nordic memory clinics. All EEGs were recorded consecutively before the diagnosis and were not used for the consensus diagnosis. Absolute and relative power was calculated for both eyes closed and open condition.
At group level using relative power, we found significant increases globally in the theta band and decreases in high frequency power in the temporal regions for eyes closed for AD and, to a lesser extent, for MCI compared to HC. Relative theta power was significantly correlated with multiple neuropsychological measures and had the largest correlation coefficient with total tau. At the individual level, the classification rate for AD and HC was 72.9% for relative power with eyes closed.
Our findings suggest that the increase in relative theta power may be the first change in patients with dementia due to AD. At the individual level, we found a moderate classification rate for AD and HC when using EEGs alone.
定量脑电图 (qEEG) 功率可能可作为阿尔茨海默病 (AD) 的诊断工具，并进一步帮助我们了解病理生理学。然而，AD 的早期 qEEG 功率变化尚不清楚。
研究 qEEG 功率的早期变化及其与记忆功能和脑脊液生物标志物的可能相关性。此外，qEEG 功率是否可以在个体水平上区分 AD、轻度认知障碍 (MCI) 和老年健康对照 (HC)。
从六个北欧记忆诊所纳入了 138 名 HC、117 名 MCI 和 117 名 AD 患者的标准 EEG。所有 EEG 均在诊断前连续记录，且未用于共识诊断。计算了闭眼和睁眼两种状态下的绝对和相对功率。
在使用相对功率的组水平上，我们发现 AD 患者的全脑 theta 波段相对功率显著增加，颞区高频功率降低，而 MCI 患者的变化程度较小。相对 theta 功率与多项神经心理学测量显著相关，与总 tau 的相关系数最大。在个体水平上，闭眼时相对功率对 AD 和 HC 的分类率为 72.9%。
我们的研究结果表明，相对 theta 功率的增加可能是 AD 患者痴呆的第一个变化。在个体水平上，我们发现仅使用 EEG 对 AD 和 HC 的分类率为中等。
