Shenton M E, Solovay M R, Holzman P S, Coleman M, Gale H J
Department of Psychiatry, Veterans Administration Medical Center, Brockton, Mass.
Arch Gen Psychiatry. 1989 Oct;46(10):897-901. doi: 10.1001/archpsyc.1989.01810100039007.
Using the Holzman-Johnston Thought Disorder Index, thought disorder was examined in the first-degree relatives of schizophrenic, manic, and schizoaffective patients. In all three groups, there was a tendency for probands with higher thought disorder to have first-degree relatives with higher thought disorder. Furthermore, the quality of thought disorder in the groups of relatives was similar to that in the groups of probands, although it was clear that the relatives of schizoaffective-manic patients showed the highest amount of thought disorder, which was not found in the proband sample. Although based on a small sample, these findings suggest that amount and type of thought disorder differ not only among medicated patient groups but also among their unmedicated relatives.
运用霍尔兹曼 - 约翰斯顿思维紊乱指数，对精神分裂症、躁狂症和分裂情感性障碍患者的一级亲属的思维紊乱情况进行了检查。在所有这三组中，思维紊乱程度较高的先证者往往有思维紊乱程度较高的一级亲属。此外，亲属组中思维紊乱的性质与先证者组相似，尽管很明显分裂情感性 - 躁狂症患者的亲属表现出的思维紊乱程度最高，而这在先证者样本中并未发现。尽管基于小样本，但这些发现表明，思维紊乱的程度和类型不仅在接受药物治疗的患者组之间存在差异，在未接受药物治疗的亲属组之间也存在差异。
