锝-99m 胱氨酸的临床评估。一种新型肾放射性药物。

Clinical evaluation of Tc-99m cystine. A new renal radiopharmaceutical.

作者信息

Misra M, Das B K, Gambhir S, Mittal B R, Sewatkar A B, Ghosh S, Banerjee S N

机构信息

Department of Nuclear Medicine, Indian Institute of Chemical Biology, Calutta.

出版信息

Clin Nucl Med. 1994 May;19(5):446-51. doi: 10.1097/00003072-199405000-00016.

DOI:10.1097/00003072-199405000-00016

PMID:8039322

Abstract

Tc-99m cystine has been proven to be a good renal agent in animals, but its clinical evaluation has not been reported. In this study, Tc-99m cystine was used for evaluation of renal function in normal subjects and patients with chronic renal failure as well as in renal transplant patients. The results are compared with similar studies that used Tc-99m DTPA and Tc-99m GHA. The clearance values also have been compared with I-131 OIH clearance. The results show that Tc-99m cystine has good radiopharmaceutical characteristics suitable for evaluation of both renal function as well as morphology.

摘要

锝-99m 胱氨酸已被证明在动物体内是一种良好的肾显像剂，但尚未见其临床评估报道。在本研究中，锝-99m 胱氨酸用于评估正常受试者、慢性肾衰竭患者以及肾移植患者的肾功能。将结果与使用锝-99m 二乙三胺五醋酸（DTPA）和锝-99m 葡庚糖酸盐（GHA）的类似研究进行比较。清除率值也与碘-131 邻碘马尿酸钠（OIH）清除率进行了比较。结果表明，锝-99m 胱氨酸具有良好的放射性药物特性，适用于评估肾功能和形态。