Virtanen S M, Räsänen L, Aro A, Ylönen K, Lounamaa R, Akerblom H K, Tuomilehto J
Department of Applied Chemistry and Microbiology, University of Helsinki, Finland.
Eur J Clin Nutr. 1994 Apr;48(4):279-85.
The study was carried out to determine whether coffee or tea consumption by the child before diagnosis of diabetes or consumption by parents at the time of the child's conception or during pregnancy was associated with the risk for childhood type 1 diabetes.
Case-control study.
All diabetic children younger than 15 years, and diagnosed from September 1986 to the end of April 1989, were invited to participate. 600 newly diagnosed diabetic children and 536 randomly selected population-based children, and their parents took part in a nationwide study.
The risk for type 1 diabetes was increased in the children who consumed at least 2 cups of coffee daily [odds ratio (OR) 1.94, 95% confidence interval (CI) 1.08-3.47], and in the children who consumed 1 cup of tea (OR 1.69, 95% CI 1.21-2.37) or at least 2 cups daily (OR 2.59, 95% CI 1.60-4.18) when adjusted for mother's education, child's age and child's sex. Parents' consumption of coffee or tea during conception of the child and mother's coffee consumption during pregnancy did not affect the risk for diabetes in the children.
We observed an increased risk for type 1 diabetes in the children who consumed coffee or tea regularly.
开展本研究以确定儿童在糖尿病诊断前饮用咖啡或茶，或父母在孩子受孕时或孕期饮用咖啡或茶是否与儿童1型糖尿病风险相关。
病例对照研究。
邀请了所有15岁以下、于1986年9月至1989年4月底被诊断出糖尿病的儿童参与研究。600名新诊断出的糖尿病儿童以及536名基于人群随机选取的儿童及其父母参与了一项全国性研究。
在对母亲教育程度、孩子年龄和孩子性别进行校正后，每天至少饮用2杯咖啡的儿童患1型糖尿病的风险增加[比值比（OR）为1.94，95%置信区间（CI）为1.08 - 3.47]，饮用1杯茶的儿童（OR为1.69，95%CI为1.21 - 2.37）或每天至少饮用2杯茶的儿童（OR为2.59，95%CI为1.60 - 4.18）患1型糖尿病的风险也增加。父母在孩子受孕时饮用咖啡或茶以及母亲在孕期饮用咖啡并不会影响孩子患糖尿病的风险。
我们观察到经常饮用咖啡或茶的儿童患1型糖尿病的风险增加。
