使用双功超声检查研究糖尿病患者的十二指肠运动和经幽门液体流动情况。

Antroduodenal motility and transpyloric fluid movement in patients with diabetes studied using duplex sonography.

作者信息

Kawagishi T, Nishizawa Y, Okuno Y, Shimada H, Inaba M, Konishi T, Morii H

机构信息

Second Department of Internal Medicine, Osaka City University Medical School, Japan.

出版信息

Gastroenterology. 1994 Aug;107(2):403-9. doi: 10.1016/0016-5085(94)90165-1.

DOI:10.1016/0016-5085(94)90165-1

PMID:8039617

Abstract

BACKGROUND/AIMS: To elucidate the relationship between diabetic autonomic neuropathy and gastrointestinal motility, antroduodenal motility was studied in patients with diabetes using duplex sonography.

METHODS

Antroduodenal motility, transpyloric fluid movement, and velocity curves of fluid flow were studied using duplex sonography in 32 patients with diabetes and 10 healthy subjects after their ingestion of a meat soup.

RESULTS

The frequency of antroduodenal coordination was significantly reduced in patients with diabetes with both early and definite autonomic neuropathy compared with healthy subjects (P < 0.05 and P < 0.01, respectively). The frequency and duration of end-cycle reflux episodes were also significantly reduced in patients with early and definite autonomic neuropathy compared with healthy subjects (P < 0.05 and P < 0.01, respectively). The frequency of end-cycle reflux episodes was closely correlated with the frequency of antroduodenal coordination in both healthy subjects (r = 0.859; P = 0.002) and patients with diabetes (r = 0.929; P = 0.0001). There was a significant correlation between fasting plasma glucose concentrations and the frequency of antroduodenal coordination in patients with diabetes (r = -0.361; P = 0.039).

CONCLUSIONS

These findings suggest that reduced frequency and duration of end-cycle reflux episodes may be an early indicator of diabetic gastroparesis that may be related mainly to autonomic neuropathy but also in part to acute hyperglycemia.

摘要

背景/目的：为阐明糖尿病自主神经病变与胃肠动力之间的关系，采用双功超声对糖尿病患者的胃十二指肠动力进行了研究。

方法

对32例糖尿病患者和10名健康受试者在摄入肉汤后，采用双功超声研究胃十二指肠动力、经幽门液体移动及液体流速曲线。

结果

与健康受试者相比，患有早期和明确自主神经病变的糖尿病患者胃十二指肠协调性频率显著降低（分别为P < 0.05和P < 0.01）。与健康受试者相比，患有早期和明确自主神经病变的患者终末周期反流发作的频率和持续时间也显著降低（分别为P < 0.05和P < 0.01）。在健康受试者（r = 0.859；P = 0.002）和糖尿病患者（r = 0.929；P = 0.0001）中，终末周期反流发作的频率与胃十二指肠协调性频率密切相关。糖尿病患者空腹血糖浓度与胃十二指肠协调性频率之间存在显著相关性（r = -0.361；P = 0.039）。